Acute pharmacological effects of α-PVP in humans : a naturalistic observational study
De la Rosa, Georgina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Caicedo, Dolly Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Argote Oramas, Martha Catalina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martín, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ventura, Mireia (Associació Benestar i Desenvolupament)
La Maida, Nunzia (National Institute of Health, Rome)
Di Trana, Annagiulia (National Institute of Health, Rome)
Graziano, Silvia (National Institute of Health, Rome)
Pichini, Simona (National Institute of Health, Rome)
Farré Albaladejo, Magí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Date:	2025
Abstract:	Alpha-pyrrolidinopentiophenone (α-PVP) is a commonly consumed analogue of pyrovalerone, a synthetic cathinone with psychostimulant properties similar to those of 3,4-Methylenedioxypyrovalerone (MDPV) and cocaine. Since the pharmacology of α-PVP remains scarcely studied, we aimed to evaluate the acute pharmacological effects and its abuse potential in humans after intranasal administration. We carried out a non-controlled observational study in a naturalistic environment in nine participants (3 women and six men) with a previous history of psychostimulant use. Participants self-administered a single intranasal dose of 10mg or 20mg of α-PVP. The outcomes included physiological effects (systolic and diastolic blood pressure, heart rate, and temperature) and subjective effects (Evaluation of Subjective Effects of Substances with Abuse Potential questionnaire_VESSPA-SSE, the short form of the Addiction Research Center Inventory questionnaire_ARCI and visual analog scales_VASs) and were measured at different time points (0, 20 and 40 minutes and 1, 1. 5, 2, 2. 5, 3, 4 and 5 hours). An acute increase in blood pressure and heart rate was observed that peaked 40 minutes after administration. Subjective effects also showed a rapid onset and disappeared 3 to 5 hours after administration. α-PVP showed psychostimulant properties similar to those displayed by cocaine and empathogenic effects commonly associated with MDMA and other cathinones (eg. methylone) consumption.
Grants:	Instituto de Salud Carlos III PI17/01962 Instituto de Salud Carlos III PI20/00879 Instituto de Salud Carlos III PI24/00834 Instituto de Salud Carlos III RD21/0009/0004 Instituto de Salud Carlos III RD24/0003/0019
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cathinones ; Alpha-pyrrolidinopentiophenone (α-PVP) ; Pharmacology ; New psychoactive substances ; Psychostimulants
Published in:	Frontiers in Pharmacology, Vol. 16 (July 2025) , ISSN 1663-9812

DOI: 10.3389/fphar.2025.1626692
PMID: 40672373

14 p, 861.6 KB

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