Mode and site of action of therapies targeting CGRP signaling
Labastida Ramírez, Alejandro (King's College London)
Caronna, Edoardo (Vall d'Hebron Institut de Recerca (VHIR))
Gollion, Cédric (University Hospital of Toulouse)
Stanyer, Emily (University of Oxford)
Dapkute, Austeja (Vilnius University)
Braniste, Diana (State University of Medicine and Pharmacy)
Naghshineh, Hoda (Tehran University of Medical Science)
Meksa, Liga (Riga East University Hospital Gailezers)
Chkhitunidze, Nino (Caucasus Medical Centre)
Gudadze, Tamari (Christian Hospital Unna)
Pozo-Rosich, Patricia (Universitat Autònoma de Barcelona. Departament de Medicina)
Burstein, Rami (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Hoffmann, Jan (King's College London)

Data:	2023
Resum:	Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Amylin ; Anti-CGRP ; Calcitonin ; Headache ; Migraine ; Trigeminal
Publicat a:	Journal of headache and pain, Vol. 24 Núm. 1 (September 2023) , ISSN 1129-2377

DOI: 10.1186/s10194-023-01644-8
PMID: 37691118

14 p, 1.3 MB

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