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| Página principal > Artículos > Artículos publicados > Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia |
(Hospital Clínic i Provincial de Barcelona) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Hospital Clínic i Provincial de Barcelona) (Institut Hospital del Mar d'Investigacions Mèdiques) (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) (Institut de Recerca Sant Pau) (FIDMAG Germanes Hospitalàries Research Foundation) (Universidad de Alcalá) (Universidad de Zaragoza) (Hospital Clínic i Provincial de Barcelona) (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) (Hospital Clínic i Provincial de Barcelona) (Centro de Investigación Biomédica en Red de Salud Mental) (Centro de Investigación Biomédica en Red de Salud Mental) (Hospital Clínic i Provincial de Barcelona) (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) (Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut de Recerca Sant Joan de Déu) (Instituto de Investigación Sanitaria de Aragón)| Fecha: | 2025 |
| Resumen: | Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the present study is to evaluate the association of MPS as a surrogate marker of the biological impact of early stressful life events (including stressful intrauterine conditions and obstetric complications, childhood adversity and toxic habits), with the risk of schizophrenia (SCZ) relapse. 91 participants from a cohort of first-episode schizophrenia (FES) patients with less than five years of evolution were classified as non-relapse (patients who had not experienced a relapse after 3 years of enrollment) or relapse (patients who relapsed during the 3-year follow-up). As inclusion criteria, patients fulfilled Andreasen's criteria of symptomatic remission. Genome-wide DNA methylation (DNAm) was profiled and fourteen MPS reflecting environmental exposure were constructed including both early stressful life events (including stressful intrauterine conditions and delivery issues, childhood adversity) and toxic habits. Increased levels of MPS reflecting gestational diabetes (p = 0. 009), hypertensive disorders during pregnancy (p = 0. 004), pre-eclampsia (p = 0. 049), early preterm birth (p = 0. 030), childhood adversity abuse (p = 0. 021) and all childhood adversity (p = 0. 030) were significantly associated with an increased risk of relapse. Our study suggests that changes in specific methylation patterns may represent one of the biological mechanisms linking early stressful life events to an increased risk of relapse. |
| Ayudas: | Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612 Instituto de Salud Carlos III PI20/00574 Generalitat de Catalunya 2021 SGR 00672 |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | DNA methylation ; Early stressful life events ; Epigenetics ; Methylation profile scores ; Relapse ; Schizophrenia |
| Publicado en: | European neuropsychopharmacology, Vol. 94 (may 2025) , p. 4-15, ISSN 1873-7862 |
