Intracorporeal vs extracorporeal anastomosis in laparoscopic right colectomy for colon cancer : a prospective multicenter cohort study (the Hemi-D-TREND study)
Serra-Aracil, Xavier (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Pascua Solé, Mireia (Consorci Sanitari de Terrassa. Hospital de Terrassa (Terrassa, Catalunya))
Sánchez Marín, Antonio (Hospital Universitari Sant Joan de Reus (Tarragona, Catalunya))
Gómez Díaz, Carlos Javier (Hospital Sant Joan de Déu (Manresa))
Ruiz, Cristina (Hospital Sant Pau i Santa Tecla (Tarragona))
Espina Perez, Beatriz (Hospital Universitari Joan XXIII de Tarragona)
Sierra, José Enrique (Hospital Universitari Arnau de Vilanova (Lleida))
Lamas, Susana (Consorci Sanitari de Terrassa. Hospital de Terrassa (Terrassa, Catalunya))
Vallverdu, Helena (Hospital Universitari de Vic)
Corredera, Constanza (Parc Sanitari Sant Joan de Déu)
Veo, Carlos (Hospital de Cancer de Barretos)
Hoyuela, Carlos (Hospital de Mollet)
Serracant, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Moreno, Felix (Hospital Universitari Sant Joan de Reus (Tarragona, Catalunya))
Collera-Ormazabal, Pablo (Hospital Sant Joan de Déu (Manresa))
Mañas, Maria José (Hospital Sant Pau i Santa Tecla (Tarragona))
Merichal, Mireia (Hospital Universitari Arnau de Vilanova (Lleida))
Cayetano-Paniagua, Ladislao (Consorci Sanitari de Terrassa. Hospital de Terrassa (Terrassa, Catalunya))
Caro, Aleidis (Hospital Universitari Joan XXIII de Tarragona)

Date:	2025
Abstract:	Background: Anastomotic leak (AL) is the most severe complication after laparoscopic right colectomy (RC), with historical median rates around 8%. Whether intracorporeal ileocolic anastomosis (ICA) offers advantages over extracorporeal anastomosis (ECA) under standardized, purely laparoscopic conditions remains uncertain. We aimed to compare AL rates and short-term postoperative outcomes between ICA and ECA in laparoscopic RC for colon cancer. Methods: Prospective multicenter cohort (TREND-compliant) across 11 hospitals (January 2019-June 2022). Adults with non-metastatic right colon cancer undergoing elective laparoscopic RC were included. Exposure (ICA vs ECA) was determined by each hospital's routine practice. Primary outcome: AL, per predefined clinical, radiologic, or endoscopic criteria. Secondary outcomes: conversion to open surgery, length of stay (LOS), complications (Clavien-Dindo), surgical site infection (SSI), and a composite of severe complications (COSC). Analyses used the full cohort; propensity score matching (PSM) was prespecified as a sensitivity analysis. Results: A total of 438 patients were analyzed: 225 ICA and 213 ECA. AL occurred in 3/225 (1. 33%) after ICA and 3/213 (1. 41%) after ECA (p = 1. 00; risk difference - 0. 08 percentage points; 95% CI - 2. 1 to 2. 3). Conversion was lower with ICA (2. 2% vs 7. 5%; p = 0. 013), while LOS was shorter with ICA (median 4 days; p < 0. 001). There were no significant differences in severe morbidity (Clavien-Dindo ≥ III: 5. 8% ICA vs 3. 8% ECA; p = 0. 375), SSI (incisional or organ/space), COSC (6. 7% ICA vs 4. 2% ECA; p = 0. 298), reoperation, or mortality. Findings were consistent in PSM analyses (213:213). Conclusions: In this prospective multicenter laparoscopic cohort, both intracorporeal and extracorporeal anastomosis achieved anastomotic-leak rates below 2%, with no superiority of one technique over the other regarding leak or severe morbidity. ICA was associated with lower conversion and shorter hospital stay. These results confirm the overall safety and feasibility of both approaches in experienced centers.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Right colectomy ; Intracorporeal anastomosis ; Extracorporeal anastomosis ; Anastomotic leak ; Laparoscopy ; Enhanced recovery
Published in:	Surgical endoscopy and other interventional techniques, Vol. 40, Num. 2 (February 2026) , p. 1559-1571, ISSN 1432-2218

DOI: 10.1007/s00464-025-12401-0

13 p, 1.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
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Articles > Published articles