Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
Minguez, B. (Hospital Sant Joan de Déu)
Paredes-Fuentes, Abraham J. (Hospital Clínic i Provincial de Barcelona)
Oliva, C. (Hospital Clínic i Provincial de Barcelona)
Rodriguez-Gonzalez, H. (Institut de Recerca Sant Joan de Déu)
Santos-Ocaña, C. (Instituto de Salud Carlos III)
Artuch, R. (Instituto de Salud Carlos III)
Santos, Mariela de los (Hospital Sant Joan de Déu)
Garcia-Volpe, Camila (Hospital Sant Joan de Déu)
Molera Busoms, Cristina (Hospital Sant Joan de Déu)
Arias, Angela (Institut de Recerca Sant Joan de Déu)
Yubero, Délia (Hospital Sant Joan de Déu)
Tondo Colomer, Mireia (Institut de Recerca Sant Pau)
Meavilla, Silvia (Hospital Sant Joan de Déu)
Universitat Autònoma de Barcelona. Departament de Medicina

Fecha:	2024
Resumen:	Coenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously. The objective of this study was to evaluate plasma CoQ, lipoprotein concentrations and CoQ/Chol ratio in a cohort of paediatric patients with different types of dyslipidaemias. A total of 60 paediatric patients were recruited (age range: 7 months-18 years), including 52 with different types of hypercholesterolemia, 2 with isolated hypertriglyceridemia and 6 with hypobetalipoproteinemia. Plasma CoQ was analysed by HPLC with electrochemical detection, and lipoprotein and cholesterol concentrations by standard automated methods. The lowest CoQ values were detected in patients with hypobetalipoproteinemia and in two cases of liver cirrhosis. Mean CoQ values were significantly higher in hypercholesterolemic patients compared to controls (average values 1. 07 µmol/L and 0. 63 µmol/L) while the CoQ/cholesterol ratio did not show differences (170 vs. 163, respectively). Mean CoQ values were significantly lower in the group of patients with hypobetalipoproteinemia compared to controls (mean CoQ values of 0. 22 µmol/L vs. 0. 63 µmol/L, respectively), while those of CoQ/cholesterol did not show differences. Pearson's correlation test showed a positive correlation between the CoQ and cholesterol values (r = 0. 565, p < 0. 001) and between the CoQ and the LDL cholesterol values (r = 0. 610, p < 0. 001). Our results suggest that it is advisable to analyse plasma CoQ and cholesterol concentrations in patients with hypobetalipoproteinemia and hypercholesterolemia associated with liver damage.
Ayudas:	Instituto de Salud Carlos III PI20/00340 Instituto de Salud Carlos III PI23/00815 Instituto de Salud Carlos III PI23/00006 Instituto de Salud Carlos III PMP22/00008
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cholesterol ; Coenzyme Q10 ; Dislipidaemia ; Hypercholesterolemia ; Hypobetalipoproteinemia ; Paediatric patients
Publicado en:	Antioxidants, Vol. 13, Num. 8 (August 2024) , p. 966, ISSN 2076-3921

DOI: 10.3390/antiox13080966
PMID: 39199213

8 p, 686.9 KB

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