Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis : Data from the Spanish Scleroderma Registry (RESCLE)
Carbonell, Cristina (Hospital Universitario de Salamanca)
Marcos, Miguel (Hospital Universitario de Salamanca)
Guillén-Del-Castillo, Alfredo (Hospital Universitari Vall d'Hebron)
Rubio Rivas, Manuel (Institut d'Investigació Biomèdica de Bellvitge)
Argibay, Ana (Complexo Hospitalario Universitario de Vigo)
Marín Ballvé, Adela (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Rodriguez-Pinto, Ignasi (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Baldà Masmiquel, Maria (Hospital Universitari de Vic. Departament de Medicina Interna)
Callejas Moraga, Eduardo Luis (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Colunga, Dolores (Hospital Universitario Central de Asturias)
Sáez-Comet, Luis (Hospital Universitario Miguel Servet (Saragossa))
González-Echávarri, Cristina (Hospital Universitario de Cruces (Barakaldo, País Basc))
Ortego-Centeno, Norberto (Hospital Universitario San Cecilio (Granada))
Marí, Begoña (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Vargas-Hitos, José Antonio (Hospital Universitario Virgen de las Nieves (Granada))
Todolí Parra, José Antonio (Hospital Universitari i Politècnic La Fe (València))
Trapiella, Luis (Hospital Universitario Central de Asturias)
Herranz-Marín, María-Teresa (Hospital General Universitario Morales Meseguer (Múrcia))
Freire, Mayka (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Castro-Salomó, Antoni (Hospital Universitari de Sant Joan de Reus (Reus, Catalunya))
Perales Fraile, Isabel (Hospital Universitario Rey Juan Carlos (Madrid))
Madroñero Vuelta, Ana Belén (Hospital General San Jorge (Osca))
Sánchez García, María Esther (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Ruiz-Muñoz, Manuel (Hospital Universitario Fundación Alcorcón)
González-García, Andrés (Hospital Universitario Ramón y Cajal (Madrid))
De la Red Bellvis, Gloria (Fundació Hospital de l'Esperit Sant)
Fernández Luque, Alejandra (Hospital de Mollet)
Muela Molinero, Alberto (Hospital Universitario de León)
Lledó, Gema María (Hospital Clínic i Provincial de Barcelona)
Tolosa-Vilella, Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Fonollosa Pla, Vicent (Hospital Universitari Vall d'Hebron)
Chamorro, Antonio-Javier (Hospital Universitario de Salamanca)
Simeón-Aznar, Carmen Pilar

Date:	2022
Description:	10 pàg.
Abstract:	Aim Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1. 48, 95% CI 1. 36-1. 60; P < 0. 001), and of lung (SIR 2. 22, 95% CI 1. 77-2. 73; P < 0. 001), breast (SIR 1. 31, 95% CI 1. 10-1. 54; P = 0. 003), and hematological (SIR 2. 03, 95% CI 1. 52-2. 62; P < 0. 001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1. 22, 95% CI 1. 01-1. 03; P < 0. 001), the presence of primary biliary cholangitis (OR 2. 35, 95% CI 1. 18-4. 68; P = 0. 015) and forced vital capacity <70% (OR 1. 8, 95% CI 1. 24-2. 70; P = 0. 002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0. 66, 95% CI 0. 45-0. 97; P = 0. 036). Conclusions Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Systemic sclerosis ; Cancer ; Anticentromere antibody ; Primary biliary cholangitis ; SDG 3 - Good Health and Well-being
Published in:	Autoimmunity Reviews, Vol. 21, Num. 10 (October 2022) , art. 103167, ISSN 1873-0183

DOI: 10.1016/j.autrev.2022.103167

10 p, 632.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles