Bioinspired neuromelanin-like Pt(iv) polymeric nanoparticles for cancer treatment
Gómez-Herrera, Roger (Institut Català de Nanociència i Nanotecnologia)
Alfonso Triguero, Paula (Institut Català de Nanociència i Nanotecnologia)
Mao, Xiaoman (Institut Català de Nanociència i Nanotecnologia)
Mancebo Aracil, Juan (Universidad Nacional del Sur (UNS))
Montpeyó Garcia-Moreno, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Ruiz Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)

Date:	2024
Description:	14 pàg.
Abstract:	To expand the chemotherapeutic potential of platinum complexes, different approaches have been followed, two of the most relevant being their administration as the prodrug Pt(iv) and encapsulation in nanocarriers. Herein, we demonstrate how neuromelanin may become a good bioinspiration for the synthesis of nanoparticles (NPs), combining both approaches. For this, complex PtBC reacts with sodium periodate, inducing a melanization process and the formation of nanoparticles. In vitro results on non-malignant human fibroblast cells (1Br3G), human cervical cancer, murine glioma (GL261), and human ovarian cancer confirmed its therapeutic efficacy. The role of the Pt(iv) ion on the cytotoxicity effects was confirmed by comparison with the results obtained for a family of nanoparticles obtained with nordihydroguaiaretic acid under the same experimental conditions. Finally, intranasal administration of the NPs in orthotopic glioblastoma multiforme murine models in female C57BL/6 mice showed excellent in vivo biodistribution and tolerability. Overall, this innovative approach represents a step toward more specific and less toxic therapies in the field of cancer chemotherapy.
Grants:	Agencia Estatal de Investigación PID2021-127983OB-C21 Agencia Estatal de Investigación PID2021-127983OB-C22 Agencia Estatal de Investigación CEX2021-001214-S Ministerio de Ciencia e Innovación CNS2022- 136106
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cancer cells ; Chemotherapy ; Melanin ; Polydopamine ; Polyphenol
Published in:	Nanotechnology Reviews, Vol. 13, Num. 1 (November 2024) , ISSN 2191-9097

DOI: 10.1515/ntrev-2024-0118

14 p, 3.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles