Limited Effectiveness of IL-17 Inhibitors for Anti-TNF-Induced Psoriasis in Hidradenitis Suppurativa : A Multicenter Retrospective Study
Bascón, Leonardo (Hospital General de Granollers)
Lluch-Galcerá, Juan José (Hospital General de Granollers)
Mora Fernández, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Verdaguer-Faja, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Haselgruber, Sofía (Hospital Universitario Virgen de las Nieves (Granada))
Molina-Leyva, Alejandro (Hospital Universitario Virgen de las Nieves (Granada))
Sin-Soler, Maria (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Garbayo-Salmons, Patricia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Mercader Salvans, Jùlia (Hospital Universitario de Canarias (La Laguna))
Lukoviek Araya, Vania (Hospital Universitario de Canarias (La Laguna))
Fernández-Crehuet, Pablo (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Parra-Navarro, Laura (Parc de Salut MAR de Barcelona)
Martin-Ezquerra, Gemma (Parc de Salut MAR de Barcelona)
Carrascosa, José Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Sampayo-Cordero, Miguel (Hospital General de Granollers)
Romaní, Jorge (Hospital General de Granollers)
Guilabert-Vidal, Antonio (Hospital General de Granollers)

Date:	2026
Abstract:	Background: Paradoxical psoriasis (PP) is a known adverse event of anti-tumor necrosis factor (anti-TNF) agents in hidradenitis suppurativa (HS), yet evidence regarding its management remains limited. The objective was to assess the effectiveness of interleukin-17 inhibitors (IL-17i) in treating anti-TNF-induced PP in patients with HS. Methods: This multicenter retrospective study included 40 adults with HS who developed PP during anti-TNF therapy and were subsequently treated with IL-17i. Outcomes for PP were measured using the Physician's Global Assessment (PGA); HS severity was evaluated using the International Hidradenitis Suppurativa Severity Score System (IHS4) and Hurley scores. Paired comparisons were performed using the Wilcoxon signed-rank or McNemar's test, as appropriate. Multivariate analysis was performed using LASSO-regularized logistic regression. Missing data were managed by multiple imputation. Results: Of the patients, 27. 5% achieved a clinically meaningful PP response, while 45% experienced worsening. Female sex, older age at HS onset, and prior exposure to secukinumab were associated with nonresponse. Conversely, HS severity improved significantly in 70% of patients (p < 0. 001). Conclusions: IL-17i showed limited effectiveness for anti-TNF-induced PP in HS, though improvement in hidradenitis was observed.
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Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Biologic therapy ; Paradoxical drug reactions ; Paradoxical psoriasis ; Hidradenitis suppurativa ; Tumour necrosis factor-alpha inhibitors ; Interleukin-17 inhibitors ; IHS4 ; Physician's global assessment
Published in:	International Journal of Dermatology, April 2026, ISSN 1365-4632

DOI: 10.1111/ijd.70420

Available from: 2027-04-30 Postprint 36 p, 817.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles