From fibro/adipogenic progenitors to adipocytes : Understanding adipogenesis in muscle degeneration for disease modulation
Villalobos, Elisa (John Walton Muscular Dystrophy Research Centre)
Mehra, Priyanka (John Walton Muscular Dystrophy Research Centre)
Diaz-Manera, Jordi (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Fecha:	2025
Resumen:	Fibro/adipogenic progenitors (FAPs) are muscle-resident stem cells essential for muscle regeneration because of their ability to differentiate into adipocytes and fibroblasts. This differentiation contributes to tissue remodelling and is implicated in the accumulation of fat and fibrotic tissue seen in neuromuscular, cardiovascular and degenerative diseases. FAPs also interact with other muscle cells and modulate inflammation, playing a central role in muscle degeneration across various disease contexts. This review summarises current knowledge on FAP adipogenic differentiation in muscle degeneration and regeneration, with a focus on cardiovascular and neuromuscular diseases, which share common features of impaired muscle remodelling. We discuss established methods for culturing, maintaining, and differentiating FAPs in vitro to support future research. Additionally, we examine FAP subpopulations, key signalling pathways and pharmacological agents influencing FAP differentiation into adipocytes. Understanding these mechanisms offers promising avenues for developing therapeutic strategies to restore muscle homeostasis and slow down pathological muscle remodelling. (Figure presented. ).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article de revisió ; recerca ; Versió publicada
Materia:	FAPs ; adipogenesis ; fibro/adipogenic progenitors ; fibrosis ; muscle ; remodelling
Publicado en:	The Journal of Physiology, Vol. 603, Num. 19 (January 2025) , p. 5273-5297, ISSN 1469-7793

DOI: 10.1113/JP288924
PMID: 40846464

25 p, 1.7 MB

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