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21.
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10 p, 2.4 MB |
Sarcoma classification by DNA methylation profiling
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Koelsche, Christian (Heidelberg University Hospital (Alemanya)) ;
Schrimpf, Daniel (German Cancer Research Center) ;
Stichel, Damian (German Cancer Research Center) ;
Sill, Martin (German Cancer Research Center) ;
Sahm, Felix (German Cancer Research Center) ;
Reuss, David E. (German Cancer Research Center) ;
Blattner, Mirjam (German Cancer Research Center) ;
Worst, Barbara (Heidelberg University Hospital (Alemanya)) ;
Heilig, Christoph E. (German Cancer Consortium) ;
Beck, Katja (German Cancer Research Center) ;
Horak, Peter (German Cancer Consortium) ;
Kreutzfeldt, Simon (German Cancer Consortium) ;
Paff, Elke (Heidelberg University Hospital (Alemanya)) ;
Stark, Sebastian (Heidelberg University Hospital (Alemanya)) ;
Johann, Pascal (Heidelberg University Hospital (Alemanya)) ;
Selt, Florian (German Cancer Research Center) ;
Ecker, Jonas (German Cancer Research Center) ;
Sturm, Dominik (Heidelberg University Hospital (Alemanya)) ;
Pajtler, Kristian W. (Heidelberg University Hospital (Alemanya)) ;
Reinhardt, Annekathrin (German Cancer Research Center) ;
Wefers, Annika K. (German Cancer Research Center) ;
Sievers, Philipp (German Cancer Research Center) ;
Ebrahimi, Azadeh (German Cancer Research Center) ;
Suwala, Abigail (German Cancer Research Center) ;
Fernández-Klett, Francisco (German Cancer Research Center) ;
Casalini, Belén (German Cancer Research Center) ;
Korshunov, Andrey (German Cancer Research Center) ;
Hovestadt, Volker (Harvard Medical School) ;
Kommoss, Felix K.F. (DHeidelberg University Hospital) ;
Kriegsmann, Mark (Heidelberg University Hospital (Alemanya)) ;
Schick, Matthias (German Cancer Research Center) ;
Bewerunge-Hudler, Melanie (German Cancer Research Center) ;
Milde, Till (German Cancer Research Center) ;
Witt, Olaf (German Cancer Research Center) ;
Kulozik, Andreas E. (eidelberg University Hospital) ;
Kool, Marcel (German Cancer Research Center) ;
Romero-Pérez, Laura (LMU Munich) ;
Grünewald, Thomas G.P. (LMU Munich) ;
Kirchner, Thomas (LMU Munich) ;
Wick, Wolfgang (German Cancer Research Center) ;
Platten, Michael (German Cancer Research Center) ;
Unterberg, Andreas (Heidelberg University Hospital (Alemanya)) ;
Uhl, Matthias (Heidelberg Institute of Radiation Oncology) ;
Abdollahi, Amir (German Cancer Research Center) ;
Debus, Jürgen (German Cancer Research Center) ;
Lehner, Burkhard (Heidelberg University Hospital (Alemanya)) ;
Thomas, Christian (University Hospital of Münster (Alemanya)) ;
Hasselblatt, Martin (University Hospital of Münster (Alemanya)) ;
Paulus, Werner (University Hospital of Münster (Alemanya)) ;
Hartmann, Christian (Hannover Medical School) ;
Staszewski, Ori (University of Freiburg) ;
Prinz, Marco (University of Freiburg) ;
Hench, Jürgen (University Hospital Basel (Basilea, Suïssa)) ;
Frank, Stephan (University Hospital Basel (Basilea, Suïssa)) ;
Versleijen-Jonkers, Yvonne M.H. (Radboud University Medical Center) ;
Weidema, Marije E. (Radboud University Medical Center) ;
Mentzel, Thomas (Dermatopathology Bodensee) ;
Griewank, Klaus (University Duisburg-Essen) ;
De Álava, Enrique (Universidad de Sevilla) ;
Díaz-Martín, Juan (Instituto de Biomedicina de Sevilla) ;
Idoate Gastearena, Miguel A. (Clínica Universidad de Navarra) ;
Chang, Kenneth Tou-En (Department of Pathology and Laboratory Medicine. KK Women's and Children's Hospital) ;
Low, Sharon Yin Yee (National Neuroscience Institute (Singapur)) ;
Cuevas-Bourdier, Adrian (Laboratoire National de Santé (França)) ;
Mittelbronn, Michel (Luxembourg Institute of Health) ;
Mynarek, Martin (University Medical Center Hamburg-Eppendorf) ;
Rutkowski, Stefan (University Medical Center Hamburg-Eppendorf) ;
Schüller, Ulrich (Research Institute Children's Cancer Center Hamburg) ;
Mautner, Viktor F. (University Medical Center Hamburg-Eppendorf) ;
Schittenhelm, Jens (Institute of Pathology and Neuropathology. University Hospital of Tübingen) ;
Serrano, Jonathan (New York University School of Medicine) ;
Snuderl, Matija (New York University School of Medicine) ;
Büttner, Reinhard (Uniklinik Köln (Colònia, Alemanya)) ;
Klingebiel, Thomas (University Children's Hospital) ;
Buslei, Rolf (Sozialstiftung Bamberg. Klinikum am Bruderwald) ;
Gessler, Manfred (Würzburg University) ;
Wesseling, Pieter (Amsterdam University Medical Centers/VUmc) ;
Dinjens, Winand N.M. (Erasmus MC Cancer Institute) ;
Brandner, Sebastian (University College London Hospitals NHS Foundation Trust) ;
Jaunmuktane, Zane (University College London) ;
Lyskjær, Iben (University College London) ;
Schirmacher, Peter (Heidelberg University Hospital (Alemanya)) ;
Stenzinger, Albretch (Heidelberg University Hospital (Alemanya)) ;
Brors, Benedikt (German Cancer Research Center) ;
Glimm, Hanno (German Cancer Consortium) ;
Heining, Christoph (German Cancer Consortium) ;
Tirado, Oscar M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Sáinz-Jaspeado, Miguel (Institut d'Investigació Biomèdica de Bellvitge) ;
Mora, Jaume (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Alonso, Javier (Instituto de Salud Carlos III) ;
Garcia del Muro, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Moran, S (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Benhamida, Jamal K. (Memorial Sloan Kettering Cancer Center) ;
Ladanyi, Marc (Department of Pathology. Memorial Sloan Kettering Cancer Center) ;
Wardelmann, Eva (University Hospital of Münster (Alemanya)) ;
Antonescu, Cristina (Memorial Sloan Kettering Cancer Center) ;
Flanagan, Adrienne (University College London Cancer Institute) ;
Dirksen, Uta (University Duisburg-Essen) ;
Hohenberger, Peter (University of Heidelberg) ;
Baumhoer, Daniel (University Hospital Basel (Basilea, Suïssa)) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Vokuhl, Christian (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Flucke, Uta (Radboud University Medical Center) ;
Petersen, Iver (Institute of Pathology) ;
Mechtersheimer, Gunhild (Heidelberg University Hospital (Alemanya)) ;
Capper, David (Charité - Universitätsmedizin Berlin) ;
Jones, David T.W. (PGerman Cancer Research Center) ;
Fröhling, Stefan (German Cancer Consortium) ;
Pfister, Stefan M. (Heidelberg University Hospital (Alemanya)) ;
von Deimling, Andreas (German Cancer Research Center)
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. [...]
2021 -  10.1038/s41467-020-20603-4
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 498
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12 p, 1.8 MB |
Innovative Bioprocess Strategies Combining Physiological Control and Strain Engineering of Pichia pastoris to Improve Recombinant Protein Production
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Gasset Franch, Arnau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Garcia-Ortega, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Garrigos, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Montesinos Seguí, José Luis (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
The combination of strain and bioprocess engineering strategies should be considered to obtain the highest levels of recombinant protein production (RPP) while assuring product quality and process reproducibility of heterologous products. [...]
2022 - 10.3389/fbioe.2022.818434
Frontiers in Bioengineering and Biotechnology, Vol. 10 (January 2022) , art. 818434
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25.
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13 p, 1.3 MB |
Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9
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Garrigos, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Weninger, Astrid (Graz University of Technology) ;
Montesinos Seguí, José Luis (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Schmid, Christian (Graz University of Technology) ;
Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Rinnofner, Claudia (Austrian Centre of Industrial Biotechnology (ACIB)) ;
Glieder, Anton (Graz University of Technology) ;
Garcia-Ortega, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
Currently, the numerous and versatile applications in pharmaceutical and chemical industry make the recombinant production of cytochrome P450 enzymes (CYPs) of great biotechnological interest. Accelerating the drug development process by simple, quick and scalable access of human drug metabolites is key for efficient and targeted drug development in response to new and sometimes unexpected medical challenges and needs. [...]
2021 - 10.1186/s12934-021-01577-4
Microbial cell factories, Vol. 20 (April 2021) , art. 90
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26.
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12 p, 1.5 MB |
Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris
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Garrigos, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Vuoristo, Kiira (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Nieto-Taype, Miguel Angel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Tähtiharju, Juha (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Uusitalo, Jaana (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Tukiainen, Pauliina (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Schmid, Christian (Bisy GmbH, Wuenschendorf 292, 8200 Hofstaetten/Raab, Austria) ;
Tolstorukov, Ilya (Keck Graduate Institute) ;
Madden, Knut (Biogrammatics Inc, 2794 Loker Ave, West, Suite 103, Carlsbad, CA 92010 USA) ;
Penttilä, Merja (VTT Technical Research Centre of Finland Ltd. Solutions for Natural Resources and Environment) ;
Montesinos Seguí, José Luis (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Glieder, Anton (Bisy GmbH, Wuenschendorf 292, 8200 Hofstaetten/Raab, Austria) ;
Garcia-Ortega, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (P), and the constitutive GAP promoter (P). [...]
2021 - 10.1186/s12934-021-01564-9
Microbial cell factories, Vol. 20 (march 2021)
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27.
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12 p, 2.3 MB |
Incidence and costs of cardiovascular events in Spanish patients with type 2 diabetes mellitus : a comparison with general population, 2015
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Jodar, Esteban (Universidad Europea de Madrid) ;
Artola, Sara (RedGDPS Foundation) ;
Garcia-Moll, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Uría, Estefany (Oblikue Consulting, S.L) ;
López-Martínez, Noemí (Oblikue Consulting, S.L) ;
Palomino, Rosa (Oblikue Consulting, S.L) ;
Martín, Virginia (Novo Nordisk Pharma SA)
Cardiovascular (CV) disease affects a high percentage of patients with type 2 diabetes mellitus (T2DM), especially in the hospital setting, impacting on mortality, complications, quality of life and use of health resources. [...]
2020 - 10.1136/bmjdrc-2019-001130
BMJ open diabetes research and care, Vol. 8 (august 2020)
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29.
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12 p, 1.9 MB |
High frequency response of thick REBCO coated conductors in the framework of the FCC study
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Romanov, Artur (Institut de Ciència de Materials de Barcelona) ;
Krkotić, Patrick (ALBA Laboratori de Llum de Sincrotró) ;
Telles, Guilherme (Institut de Ciència de Materials de Barcelona) ;
O'Callaghan, Joan (Universitat Politècnica de Catalunya) ;
Pont, Montse (ALBA Laboratori de Llum de Sincrotró) ;
Perez, Francis (ALBA Laboratori de Llum de Sincrotró) ;
Granados García, Xavier (Institut de Ciència de Materials de Barcelona) ;
Calatroni, Sergio (CERN) ;
Puig i Molina, Mª Teresa (Institut de Ciència de Materials de Barcelona) ;
Gutiérrez, Joffre (Institut de Ciència de Materials de Barcelona)
A thorough microwave response study of high temperature superconductors, considered as an alternative beam screen coating, has become integral in the design decisions for CERN's future research infrastructure. [...]
2020 - 10.1038/s41598-020-69004-z
Scientific reports, Vol. 10 (July 2020) , art. 12325
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30.
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21 p, 2.7 MB |
Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory
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Nieto-Taype, Miguel Angel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Garcia-Ortega, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Albiol i Sala, Joan (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Montesinos Seguí, José Luis (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
The methylotrophic yeast Pichia pastoris (Komagataella phaffii) is currently considered one of the most promising hosts for recombinant protein production (RPP) and metabolites due to the availability of several tools to efficiently regulate the recombinant expression, its ability to perform eukaryotic post-translational modifications and to secrete the product in the extracellular media. [...]
2020 - 10.3389/fbioe.2020.00632
Frontiers in Bioengineering and Biotechnology, Vol. 8 (June 2020) , art. 632
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