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36 p, 4.7 MB

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer / García-Vílchez, Raquel (Instituto de Investigación Biomédica de Salamanca) ; Añazco-Guenkova, Ana M. (Instituto de Investigación Biomédica de Salamanca) ; Dietmann, Sabine (Washington University School of Medicine in St. Lou) ; López, Judith (Instituto de Investigación Biomédica de Salamanca) ; Morón-Calvente, Virginia (Instituto de Investigación Biomédica de Salamanca) ; D'Ambrosi, Silvia (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Nombela, Paz (Instituto de Investigación Biomédica de Salamanca) ; Zamacola, Kepa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Mendizabal, Isabel (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; García-Longarte, Saioa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ; Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ; Fernández, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ; Paniagua, Alejandro (Universidad de Salamanca) ; Miguel-López, Borja (Instituto de Investigación Biomédica de Salamanca) ; Marchand, Virginie (Université de Lorraine, France) ; Alonso-López, Diego (Universidad de Salamanca) ; Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Tuñón, Ignacio (Universidad de Salamanca) ; Ugalde-Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ; Loizaga-Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ; Lacasa-Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ; Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ; Azkargorta, Mikel (Carlos III Networked Proteomics Platform (ProteoRed-ISCIII), Madrid) ; Elortza, Félix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Bárcena, Laura (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Gonzalez-Lopez, Monika (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Di Domenico, Tomás (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO)) ; Sánchez-Martín, Manuel A. (Universidad de Salamanca) ; De Las Rivas, Javier (Universidad de Salamanca) ; Guil, S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Motorin, Yuri (Université de Lorrain) ; Helm, Mark (Johannes Gutenberg-University Mainz, Germany) ; Pandolfi, Pier Paolo (University of Turin, Italy) ; Carracedo, Arkaitz (Centro de Investigación Biomédica en Red de Cáncer) ; Blanco, Sandra (Universidad de Salamanca)
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. [...]
2023 - DOI (Digital Object Identifier)

10.1186/s12943-023-01809-8
Molecular cancer, Vol. 22 Núm. 1 (july 2023)

Detailed record -

14 p, 7.4 MB

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors / Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ; Ensenyat Méndez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ; Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ; Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ; Matsuba, Chikako (University of Southern California, Los Angeles, USA) ; Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ; Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ; Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ; Unzueta, Fernando (Universitat de Barcelona) ; Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ; Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ; Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ; Cortés, Javier (Universidad Europea de Madrid) ; DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lupien, Mathieu (University of Toronto) ; Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - DOI (Digital Object Identifier)

10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)

Detailed record -

15 p, 4.7 MB

Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer / Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ; Zhang, Pei Hong (Fudan University, Shanghai, China) ; Yang, Li (Fudan University, Shanghai, China) ; Guarnacci, Marco (Australian National University, Canberra, Australia) ; Schumann, Ulrike (Australian National University, Canberra, Australia) ; Preiss, Thomas (Australian National University, Canberra, Australia) ; Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ; Montal, Robert (Universitat de Lleida) ; Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 - DOI (Digital Object Identifier)

10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)

Detailed record -

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