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16 p, 3.1 MB Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases / Loch, Rolf Antonie (Scherrer Institute (Suïssa). Department of Biology and Chemistry) ; Wang, Hongzhi (Paul Scherrer Institute (Suïssa). Department of Biology and Chemistry) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Berger, Philipp (Scherrer Institute (Suïssa). Department of Biology and Chemistry) ; Nielsen, Henrietta (Stockholm University. Department of Biochemistry and Biophysics) ; Chroni, Angeliki (National Center for Scientific Research 'Demokritos' (Grècia)) ; Luo, Jinghui (Scherrer Institute (Suïssa). Department of Biology and Chemistry)
Three common Apolipoprotein E isoforms, ApoE2, ApoE3, and ApoE4, are key regulators of lipid homeostasis, among other functions. Apolipoprotein E can interact with amyloid proteins. The isoforms differ by one or two residues at positions 112 and 158, and possess distinct structural conformations and functions, leading to isoform-specific roles in amyloid-based neurodegenerative diseases. [...]
2023 - 10.1016/j.csbj.2023.01.022
Computational and Structural Biotechnology Journal, Vol. 21 (january 2023) , p. 1189-1204  
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