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Published articles 2 records found  Search took 0.00 seconds. 
1.
15 p, 2.1 MB Evolution of complexity in the zebrafish synapse proteome / Bayés, Àlex (Institut d'Investigació Biomèdica Sant Pau) ; Collins, Mark O. (University of Sheffield) ; Reig-Viader, R. (Institut d'Investigació Biomèdica Sant Pau) ; Gou Alsina, Gemma (Institut d'Investigació Biomèdica Sant Pau) ; Goulding, David (Wellcome Trust Sanger Institute (Regne Unit)) ; Izquierdo, Abril (University of Nottingham) ; Choudhary, Jyoti S. (Wellcome Trust Sanger Institute (Regne Unit)) ; Emes, Richard D. (University of Nottingham) ; Grant, Seth G. N. (University of Edinburgh) ; Universitat Autònoma de Barcelona
The proteome of human brain synapses is highly complex and is mutated in over 130 diseases. This complexity arose from two whole-genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases; however, its synapse proteome is uncharacterized, and whether the teleost-specific genome duplication (TSGD) influenced complexity is unknown. [...]
2017 - 10.1038/ncomms14613
Nature communications, Vol. 8 (03 2017)  
Detailed record - Creative Commons
2.
9 p, 2.4 MB Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP / Klementieva, O. (Lund University. Department of Experimental Medical Science) ; Willén, K. (Lund University. Department of Experimental Medical Science) ; Martinsson, Isak (Lund University. Department of Experimental Medical Science) ; Israelsson, B. (Lund University. Department of Experimental Medical Science) ; Engdahl, A. (Lund University. MAX IV Laboratory) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Uvdal, P. (Lund University. Department of Chemistry) ; Gouras, G. K. (Lund University. Department of Experimental Medical Science)
Reducing levels of the aggregation-prone Aβ peptide that accumulates in the brain with Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative approach may be to stabilize the physiological conformation of Aβ. [...]
2017 - 10.1038/ncomms14726
Nature communications, Vol. 8 (March 2017) , art. 14726  
Detailed record - Creative Commons

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