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14 p, 445.0 KB Targeting HER2 in non-small-cell lung cancer (NSCLC) : a glimpse of hope? An updated review on therapeutic strategies in NSCLC harbouring HER2 alterations / Riudavets, M. (Department of Cancer Medicine. Gustave Roussy Cancer Campus) ; Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ; Abdayem, P. (Department of Cancer Medicine. Gustave Roussy Cancer Campus) ; Planchard, D. (Department of Cancer Medicine. Gustave Roussy Cancer Campus)
Non-small-cell lung cancer (NSCLC) harbouring HER2 alterations is now considered a distinct molecular subtype. The activation of HER2 in NSCLC occurs via three mechanisms, i. e. gene mutation (1%-4% of cases), gene amplification (2%-5%) and protein overexpression (2%-30%), with different prognostic and predictive outcomes. [...]
2021 - 10.1016/j.esmoop.2021.100260
ESMO open, Vol. 6 Núm. 5 (october 2021) , p. 100260  

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