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BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice / Hoffmann, Jenny M. (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Grünberg, John R. (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Hammarstedt, Ann (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Kroon, Tobias (BioPharmaceuticals. Bioscience Metabolism, Research and Early Development) ; Greiner, Thomas U. (University of Gothenburg. Department of Molecular and Clinical Medicine) ; Maurer, Stefanie (BioPharmaceuticals. Bioscience Metabolism, Research and Early Development) ; Elias Puigdomenech, Ivet (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Palsdottir, Vilborg (University of Gothenburg. Department of Physiology/Endocrinology) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Boucher, Jeremie (University of Gothenburgç. Wallenberg Centre for Molecular and Translational Medicine) ; Hedjazifar, Shahram (University of Gothenburg. The Lundberg Laboratory for Diabetes Research) ; Smith, Ulf (University of Gothenburg. The Lundberg Laboratory for Diabetes Research)
Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. [...]
2019 - DOI (Digital Object Identifier)

10.1016/j.molmet.2019.11.016
Molecular metabolism, Vol. 32 (december 2019) , p. 15-26

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