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9 p, 1.2 MB BCG vaccination to reduce the impact of COVID-19 in healthcare workers : Protocol for a randomised controlled trial (BRACE trial) / Pittet, Laure F (The Royal Children's Hospital Melbourne) ; Messina, Nicole L (The University of Melbourne) ; Gardiner, Kaya (Murdoch Children's Research Institute) ; Orsini, Francesca (Murdoch Children's Research Institute) ; Abruzzo, Veronica (Murdoch Children's Research Institute) ; Bannister, Samantha (The Royal Children's Hospital Melbourne) ; Bonten, Marc (Julius Center for Health Sciences and Primary Care) ; Campbell, John L (University of Exeter Medical School) ; Croda, Julio (Yale School of Public Health) ; Dalcolmo, Margareth (Pontifical Catholic University of Rio de Janeiro) ; Elia, Sonja (The Royal Children's Hospital Melbourne) ; Germano, Susie (Murdoch Children's Research Institute) ; Goodall, Casey (Murdoch Children's Research Institute) ; Gwee, Amanda (The Royal Children's Hospital Melbourne) ; Jamieson, Tenaya (Murdoch Children's Research Institute) ; Jardim, Bruno (Fundação de Medicina Tropical Doutor Heitor Vieira Dourado) ; Kollmann, Tobias R (Telethon Kids Institute) ; Guimarães Lacerda, Marcus Vinícius (Fundação Oswaldo Cruz (Brasil)) ; Lee, Katherine J (Murdoch Children's Research Institute) ; Legge, Donna (Royal Children's Hospital Melbourne) ; Lucas, Michaela (The University of Western Australia) ; Lynn, David J (Flinders University) ; McDonald, Ellie (Murdoch Children's Research Institute) ; Manning, Laurens (Fiona Stanley Hospital (Perth, Austràlia)) ; Munns, Craig F (The University of Sydney) ; Perrett, Kirsten P (Murdoch Children's Research Institute) ; Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Richmond, Peter (The University of Western Australia) ; Shann, Frank (The Royal Children's Hospital Melbourne) ; Sudbury, Eva (Murdoch Children's Research Institute) ; Villanueva, Paola (The University of Melbourne) ; Wood, Nicholas J (National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases) ; Lieschke, Katherine (Murdoch Children's Research Institute) ; Subbarao, Kanta (The Peter Doherty Institute for Infection and Immunity) ; Davidson, Andrew (Murdoch Children's Research Institute) ; Curtis, Nigel (The Royal Children's Hospital Melbourne) ; Universitat Autònoma de Barcelona
BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established safety profile, BCG is a good candidate for protecting healthcare workers (HCWs) and other vulnerable groups against COVID-19. [...]
2021 - 10.1136/bmjopen-2021-052101
BMJ open, Vol. 11 (october 2021)  
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