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15 p, 2.0 MB Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability / Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ruiz, Anne (Centre de Recherche en Neurosciences de Lyon) ; Richard, Chloé (Centre de Recherche en Neurosciences de Lyon) ; Blondel, Sandrine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cavagna, Sylvie (Centre de Recherche en Neurosciences de Lyon) ; Strazielle, Nathalie (BIP Facility (França)) ; Ghersi-Egea, Jean-François (BIP Facility (França)) ; Giraudon, Pascale (Centre de Recherche en Neurosciences de Lyon) ; Marignier, Romain (Centre de Recherche en Neurosciences de Lyon) ; Universitat Autònoma de Barcelona
Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte. Although blood-brain barrier (BBB) breakdown is considered one of the key steps for the development and lesion formation, little is known about the molecular mechanisms involved. [...]
2020 - 10.1371/journal.pone.0238301
PloS one, Vol. 15 (september 2020)  

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