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13 p, 2.9 MB Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation / Castellví Toledo, Albert (ALBA Laboratori de Llum de Sincrotró) ; Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Crosas, Eva (ALBA Laboratori de Llum de Sincrotró) ; Cámara-Artigas, Ana (Universidad de Almería) ; Gavira, José A. (Universidad de Granada) ; Aranda, Miguel A. G. (ALBA Laboratori de Llum de Sincrotró) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Juanhuix, Judith (ALBA Laboratori de Llum de Sincrotró)
Human aldose reductase (hAR, AKR1B1) has been explored as drug target since the 1980s for its implication in diabetic complications. An activated form of hAR was found in cells from diabetic patients, showing a reduced sensitivity to inhibitors in clinical trials, which may prevent its pharmacological use. [...]
2019 - 10.1038/s41598-019-39722-0
Scientific reports, Vol. 9 (February 2019) , art. 3177  
Detailed record - Creative Commons

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