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21 p, 12.7 MB NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness / Bachiller, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pérez-Amill, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Battram, Anthony M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Carné, Sebastian Ciro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Najjar, Amer (The University of Texas MD Anderson Cancer Center) ; Verhoeyen, Els (Université Côte d'Azur) ; Juan, Manel (Universitat de Barcelona. Departament de Medicina) ; Urbano-Ispizua, Alvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martín-Antonio, B (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Universitat Autònoma de Barcelona
Background Chimeric antigen receptor (CAR)-T cell immunotherapy has modified the concept of treatment in hematological malignancies. In comparison with pediatric patients, where responses are maintained over many years, older patients, such as those with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM), present lower persistence of CAR-T cells that might be due to decreased fitness of T cells acquired with aging. [...]
2021 - 10.1136/jitc-2021-002866
Journal for immunotherapy of cancer, Vol. 9 Núm. 8 (25 2021) , p. 2866  

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