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1.
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15 p, 1.6 MB |
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
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Chen, Jiajin (Nanjing Medical University) ;
Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ;
Li, Yi (Department of Biostatistics. University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ;
Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ;
You, Dongfang (Department of Biostatistics. Nanjing Medical University) ;
Su, Li (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ;
Karlsson, Anna (Department of Clinical Sciences. Lund University) ;
Planck, Maria (Department of Clinical Sciences. Lund University) ;
Staaf, Johan (Department of Clinical Sciences. Lund University) ;
Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M (Universitat de Barcelona) ;
Shen, Hongbing (Nanjing Medical University) ;
Christiani, David C. (Harvard Medical School) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 -  10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187
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2.
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15 p, 2.0 MB |
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC
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Ji, Xinyu (Nanjing Medical University) ;
Lin, Lijuan (Nanjing Medical University) ;
Fan, Juanjuan (Nanjing Medical University) ;
Li, Yi (University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Nanjing Medical University) ;
Su, Li (Harvard T.H. Chan School of Public Health (Estats Units d'Amèrica)) ;
Shafer, Andrea (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Oslo University Hospital (Oslo, Noruega)) ;
Karlsson, Anna (Lund University) ;
Planck, Maria (Lund University) ;
Staaf, Johan (Lund University) ;
Helland, Åslaug (University of Oslo) ;
Esteller, M (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (Nanjing Medical University) ;
Christiani, David C (Harvard Medical School) ;
Universitat Autònoma de Barcelona
The interaction between DNA methylation of tripartite motif containing 27 (cg05293407) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small-cell lung cancer (NSCLC) survival. [...]
2022 - 10.1002/1878-0261.13167
Molecular Oncology, Vol. 16 Núm. 3 (february 2022) , p. 717-731
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3.
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16 p, 1.9 MB |
Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients
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Ji, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Lin, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Shen, S. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Dong, X. (Department of Epidemiology and Biostatistics. School of Public Health. Southeast University) ;
Chen, C. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Li, Y. (Department of Biostatistics. University of Michigan) ;
Zhu, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Huang, H. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Wei, Liangmin (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
He, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Duan, W. (Department of Bioinformatics. School of Biomedical Engineering and Informatics. Nanjing Medical University) ;
Su, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Jiang, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Fan, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Guan, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
You, D. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Shafer, A. (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Karlsson, A. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Planck, M. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Staaf, J. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Helland, Å. (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wei, Y. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Zhang, R. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Chen, F. (Jiangsu Key Lab of Cancer Biomarkers. Prevention and Treatment. Cancer Center. Collaborative Innovation Center for Cancer Personalized Medicine. Nanjing Medical University) ;
Christiani, David C (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. [...]
2020 - 10.1002/1878-0261.12785
Molecular Oncology, Vol. 14 Núm. 11 (january 2020) , p. 2759-2774
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4.
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12 p, 1.2 MB |
Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects
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Zhang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Chen, C. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Dong, X. (Department of Epidemiology and Biostatistics. School of Public Health. Southeast University) ;
Shen, S. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Lai, L. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
He, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
You, D. (Department of Environmental Health. Harvard T. H. Chan School of Public Health) ;
Lin, L. (Department of Environmental Health. Harvard T. H. Chan School of Public Health) ;
Zhu, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Huang, H. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Wei, Liangmin (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Li, Y. (Department of Biostatistics. University of Michigan) ;
Guo, Y. (Department of Biostatistics. Harvard T. H. Chan School of Public Health) ;
Duan, W. (Department of Bioinformatics. School of Biomedical Engineering and Informatics. Nanjing Medical University) ;
Liu, L. (Department of Preventive Medicine. Medical School of Ningbo University) ;
Su, L. (Department of Environmental Health. Harvard T. H. Chan School of Public Health) ;
Shafer, A. (Harvard Medical School) ;
Fleischer, T. (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Moksnes Bjaanæs, M. (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Karlsson, A. (Division of Oncology and Pathology. Department of Clinical Sciences. Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Planck, M. (Division of Oncology and Pathology. Department of Clinical Sciences. Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Wang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Staaf, J. (Division of Oncology and Pathology. Department of Clinical Sciences. Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Helland, Å. (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M. (Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut) ;
Wei, Y. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Chen, F. (Jiangsu Key Laboratory of Cancer Biomarkers. Prevention and Treatment. Cancer Center. Collaborative Innovation Center for Cancer Personalized Medicine. Nanjing Medical University) ;
Christiani, David C (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Background: DNA methylation and gene expression are promising biomarkers of various cancers, including non-small cell lung cancer (NSCLC). Besides the main effects of biomarkers, the progression of complex diseases is also influenced by gene-gene (G×G) interactions. [...]
2020 - 10.1016/j.chest.2020.01.048
Chest, Vol. 158 Núm. 2 (august 2020) , p. 808-819
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5.
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21 p, 2.7 MB |
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
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Chen, C. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Wei, Y. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Wei, Liangmin (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Dong, X. (Department of Epidemiology and Biostatistics. School of Public Health. Southeast University) ;
He, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Lin, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Zhu, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Huang, H. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
You, D. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Lai, L. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Shen, S. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Duan, W. (Department of Bioinformatics. School of Biomedical Engineering and Informatics. Nanjing Medical University) ;
Su, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Shafer, A. (Harvard Medical School) ;
Fleischer, T. (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Karlsson, A. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Planck, M. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Wang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Staaf, J. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Helland, Å. (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zhang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Chen, F. (Jiangsu Key Lab of Cancer Biomarkers. Prevention and Treatment. Cancer Center. Collaborative Innovation Center for Cancer Personalized Medicine. Nanjing Medical University) ;
Christiani, David C (Harvard Medical School) ;
Universitat Autònoma de Barcelona
DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. [...]
2020 - 10.18632/aging.103284
Aging (Albany NY), Vol. 12 Núm. 11 (15 2020) , p. 10642-10662
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