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14 p, 2.7 MB Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist / Moreau, Francois (Harvard Medical School. Joslin Diabetes Center) ; Kirk, Nicholas S. (University of Melbourne. Department of Medical Biology) ; Zhang, Fa (Indiana University. Department of Chemistry) ; Gelfanov, Vasily (Indianapolis Research Center) ; List, Edward O. (Ohio University. Edison Biotechnology Institute and Heritage College of Osteopathic Medicine) ; Chrudinová, Martina (Boston College Biology Department) ; Venugopal, Hari (Monash University. Ramaciotti Centre for Cryo-Electron Microscopy) ; Lawrence, Michael C. (University of Melbourne. Department of Medical Biology) ; Jimenez, Veronica (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Kopchick, John J. (Ohio University. Edison Biotechnology Institute and Heritage College of Osteopathic Medicine) ; DiMarchi, Richard D. (Indiana University. Department of Chemistry) ; Altindis, Emrah (Boston College Biology Department) ; Ronald Kahn, C. (Harvard Medical School. Joslin Diabetes Center)
Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high homology to human insulin and IGFs. Here we show that while single-chain (sc) and double-chain (dc) LCDV1-VILPs have very low affinity for the insulin receptor, scLCDV1-VILP has high affinity for IGF1R where it can antagonize human IGF-1 signaling, without altering insulin signaling. [...]
2022 - 10.1038/s41467-022-34391-6
Nature communications, Vol. 13 (november 2022)  
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