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1.
14 p, 4.6 MB Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors / Lassi, Maximilian (German Center for Diabetes Research (DZD)) ; Tomar, Archana (German Center for Diabetes Research (DZD)) ; Comas-Armangué, Gemma (German Center for Diabetes Research (DZD)) ; Vogtmann, Rebekka (University Hospital Essen. Department of Gynecology and Obstetrics) ; Dijkstra, Dorieke J. (University of Groningen. Department of Obstetrics and Gynecology) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gerlini, Raffaelle (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Darr, Jonatan (German Center for Diabetes Research (DZD)) ; Scheid, Fabienne (German Center for Diabetes Research (DZD)) ; Rozman, Jan (Czech Centre for Phenogenomics. Institute of Molecular Genetics of the Czech Academy of Sciences. BIOCEV) ; Aguilar-Pimentel, Antonio (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Koren, Omry (Azrieli Faculty of Medicine. Bar Ilan University) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fuchs, Helmut (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Marschall, Susan (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Gailus-Durner, Valerie (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan) ; Plösch, Torsten (University of Groningen. Department of Obstetrics and Gynecology) ; Gellhaus, Alexandra (Department of Gynecology and Obstetrics. University Hospital Essen) ; Teperino, Raffaele (German Center for Diabetes Research (DZD))
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. [...]
2021 - 10.1126/sciadv.abg6424
Science advances, Vol. 7 Núm. 22 (may 2021) , p. eabg6424  
Registre complet - Creative Commons
2.
16 p, 2.3 MB Identification of genetic elements in metabolism by high-throughput mouse phenotyping / Rozman, Jan (German Center for Diabetes Research) ; Rathkolb, Birgit (Ludwig Maximilians Universität München. Institute of Molecular Animal Breeding and Biotechnology) ; Oestereicher, Manuela A. (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Schütt, Christine (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Ravindranath, Aakash Chavan (Helmholtz Zentrum München. Institute of Bioinformatics and Systems Biology) ; Leuchtenberger, Stefanie (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Sharma, Sapna (Helmholtz Zentrum München. Institute of Epidemiology II) ; Kistler, Martin (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Willershäuser, Monja (Technical University of Munich. Institute for Food and Health) ; Brommage, Robert (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Meehan, Terrence F. (European Bioinformatics Institute) ; Mason, Jeremy (European Bioinformatics Institute) ; Haselimashhadi, Hamed (European Bioinformatics Institute) ; Hough, Tertius (Medical Research Council Harwell) ; Mallon, Ann-Marie (Medical Research Council Harwell) ; Wells, Sara (Medical Research Council Harwell) ; Santos, Luis (Medical Research Council Harwell) ; Lelliott, Christopher J. (Wellcome Trust Sanger Institute (Regne Unit)) ; White, Jacqueline K. (The Jackson Laboratory) ; Sorg, Tania (Université de Strasbourg) ; Champy, Marie-France (Université de Strasbourg) ; Bower, Lynette R. (University of California. Mouse Biology Program) ; Reynolds, Corey L. (Baylor College of Medicine. Department of Molecular and Human Genetics) ; Flenniken, Ann M. (Mount Sinai Hospital) ; Murray, Stephen A. (The Jackson Laboratory) ; Nutter, Lauryl M. J. (The Hospital for Sick Children) ; Svenson, Karen L. (The Jackson Laboratory) ; West, David (Children's Hospital Oakland Research Institute) ; Tocchini-Valentini, Glauco P. (Monterotondo Mouse Clinic. Institute of Cell Biology and Neurobiology) ; Beaudet, Arthur L. (The Hospital for Sick Children) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Braun, Robert B. (The Jackson Laboratory) ; Dobbie, Michael S. (Australian National University) ; Gao, Xiang (Nanjing University. Collaborative Innovation Center for Genetics and Development) ; Herault, Yann (Université de Strasbourg) ; Moshiri, Ala (School of Medicine U.C. Davis. Department of Ophthalmology and Vision Science) ; Moore, Bret A. (School of Veterinary Medicine U.C. Davis) ; Lloyd, Kent (University of California) ; McKerlie, Colin (The Hospital for Sick Children) ; Masuya, Hiroshi (RIKEN BioResource Center) ; Tanaka, Nobuhiko (RIKEN BioResource Center) ; Flicek, Paul (European Bioinformatics Institute) ; Parkinson, Helen E. (European Bioinformatics Institute) ; Sedlacek, Radislav (Institute of Molecular Genetics. Czech Centre for Phenogenomics) ; Seong, Je Kyung (Seoul National University. College of Veterinary Medicine) ; Wang, Chi-Kuang Leo (National Laboratory Animal Center) ; Moore, Mark (International Mouse Phenotyping Consortium) ; Brown, Steve D. M (Medical Research Council Harwell) ; Tschöp, Matthias H. (Technische Universität München. Department of Medicine) ; Wurst, Wolfgang (Ludwig Maximilians Universität München. Adolf Butenandt Institut) ; Klingenspor, Martin (Technical University of Munich. Institute for Food & Health) ; Wolf, Eckhard (Ludwig Maximilians Universität München. Institute of Molecular Animal Breeding and Biotechnology) ; Beckers, Johannes (Technische Universität München. School of Life Science Weihenstephan) ; Machicao, Fausto (University of Tübingen. Department of Internal Medicine) ; Peter, Andreas (Eberhard Karls University of Tuebingen. Institute for Diabetes Research and Metabolic Diseases) ; Staiger, Harald (Eberhard Karls University Tübingen. Department of Pharmacy and Biochemistry) ; Häring, Hans-Ulrich (Eberhard Karls University of Tuebingen. Institute for Diabetes Research and Metabolic Diseases) ; Grallert, Harald (Ludwig-Maximilians-Universität München) ; Campillos, Monica (Helmholtz Zentrum München. Institute of Bioinformatics and Systems Biology) ; Maier, Holger (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Fuchs, Helmut (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Gailus-Durner, Valerie (Helmholtz Zentrum München. Institute of Experimental Genetics) ; Werner, Thomas (University of Michigan. Internal Medicine Nephrology and Center for Computational Medicine and Bioinformatics) ; De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan)
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. [...]
2018 - 10.1038/s41467-017-01995-2
Nature communications, Vol. 9 (January 2018) , art. 288  
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