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12 p, 1.4 MB Heterologous Systemic Prime-Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters / Katsande, Paidamoyo M. (Royal Holloway University of London. Department of Biological Sciences) ; Fernández-Bastit, Leira (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Ferreira, William T. (SporeGen Ltd. London Bioscience Innovation Centre) ; Vergara-Alert, Júlia (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Hess, Mateusz (Royal Holloway University of London. Department of Biological Sciences) ; Lloyd-Jones, Katie (Royal Holloway University of London. Department of Biological Sciences) ; Hong, Huynh A. (Royal Holloway University of London. Department of Biological Sciences) ; Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Cutting, Simon M. (Royal Holloway University of London. Department of Biological Sciences)
Background : Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are administered systemically and typically result in poor immunogenicity at the mucosa. As a result, vaccination is unable to reduce viral shedding and transmission, ultimately failing to prevent infection. [...]
2022 - 10.3390/vaccines10111900
Vaccines (Basel), Vol. 10 (november 2022)  

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