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812.9 KB ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs / Moon, Katherine L. (University of California. Department of Ecology and Evolutionary Biology) ; Huson, Heather J. (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ; Morrill, Kathleen (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Wang, Ming-Shan (University of California. Howard Hughes Medical Institute) ; Li, Xue (Broad Institute of MIT and Harvard) ; Srikanth, Krishnamoorthy (Cornell University College of Agriculture and Life Sciences. Department of Animal Sciences) ; Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry & Microbiology) ; Svenson, Gavin J. (Cleveland Museum of Natural History) ; Karlsson, Elinor K. (University of Massachusetts Medical School. Bioinformatics and Integrative Biology) ; Shapiro, Beth (University of California. Department of Ecology and Evolutionary Biology)
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. [...]
2023 - 10.1126/science.abn5887
Science, Vol. 380 Num. 6643 (April 2023) , art. eabn5887  
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