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11 p, 3.1 MB Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections / Moreno-Molina, Miguel (Instituto de Biomedicina de Valencia (IBV-CSIC)) ; Shubladze, Natalia (National Center for Tuberculosis and Lung Diseases of Georgia) ; Khurtsilava, Iza (National Center for Tuberculosis and Lung Diseases of Georgia) ; Avaliani, Zaza (National Center for Tuberculosis and Lung Diseases of Georgia) ; Bablishvili, Nino (National Center for Tuberculosis and Lung Diseases of Georgia) ; Torres-Puente, Manuela (Instituto de Biomedicina de Valencia (IBV-CSIC)) ; Villamayor, Luis (FISABIO Public Health) ; Gabrielian, Andrei (National Institutes of Health. Department of Health and Human Services (Estats Units d'Amèrica)) ; Rosenthal, Alex (National Institutes of Health. Department of Health and Human Services (Estats Units d'Amèrica)) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gagneux, Sebastien (University of Basel) ; Kempker, Russell R. (Emory University School of Medicine. Department of Medicine) ; Vashakidze, Sergo (National Center for Tuberculosis and Lung Diseases of Georgia) ; Comas, I (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Universitat Autònoma de Barcelona
Polyclonal infections occur when at least two unrelated strains of the same pathogen are detected in an individual. This has been linked to worse clinical outcomes in tuberculosis, as undetected strains with different antibiotic resistance profiles can lead to treatment failure. [...]
2021 - 10.1038/s41467-021-22705-z
Nature communications, Vol. 12 (may 2021)  
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