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14 p, 425.7 KB Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC : Primary and Correlative Biomarker Analyses / Owonikoko, Taofeek K. (Winship Cancer Institute of Emory University) ; Niu, Huifeng (Millennium Pharmaceuticals. Inc.) ; Nackaerts, Kristiaan (KU Leuven. Universitaire Ziekenhuizen) ; Csoszi, Tibor (Hetenyi G Korhaz) ; Ostoros, Gyula (Orszagos Koranyi TBC es Pulmonologiai Intezet) ; Mark, Zsuzsanna (Tudogyogyintezet Torokbalint) ; Baik, Christina (University of Washington Seattle Cancer Care Alliance) ; Joy, Anil Abraham (University of Alberta. Cross Cancer Institute) ; Chouaid, Christos (CHI de Créteil) ; Jaime, Jesus Corral (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Kolek, Vitezslav (Fakultni Nemocnice Olomouc) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Roubec, Jaromir (Fakultni Nemocnice Ostrava) ; Santos, Edgardo S. (Lynn Cancer Institute/Boca Raton Regional Hospital) ; Chiang, Anne C. (Yale University School of Medicine) ; Speranza, Giovanna (Université de Sherbrooke) ; Belani, Chandra P. (Penn State Cancer Institute) ; Chiappori, Alberto (H. Lee Moffitt Cancer Center) ; Patel, Manish R. (Florida Cancer Specialists/Sarah Cannon Research Institute) ; Czebe, Krisztina (Tudogyogyintezet Torokbalint) ; Byers, Lauren (Tudogyogyintezet Torokbalint) ; Bahamon, Brittany (Millennium Pharmaceuticals. Inc.) ; Li, Cong (Millennium Pharmaceuticals. Inc.) ; Sheldon-Waniga, Emily (Millennium Pharmaceuticals. Inc.) ; Kong, Eric F. (University of Texas M. D. Anderson Cancer Center) ; Williams, Miguel (Millennium Pharmaceuticals. Inc.) ; Badola, Sunita (Millennium Pharmaceuticals. Inc.) ; Shin, Hyunjin (Millennium Pharmaceuticals. Inc.) ; Bedford, Lisa (Millennium Pharmaceuticals. Inc.) ; Ecsedy, Jeffrey A. (Millennium Pharmaceuticals. Inc.) ; Bryant, Matthew (University of Texas M. D. Anderson Cancer Center) ; Jones, Sian (University of Texas M. D. Anderson Cancer Center) ; Simmons, John (University of Texas M. D. Anderson Cancer Center) ; Leonard, E. Jane (Millennium Pharmaceuticals. Inc.) ; Ullmann, Claudio Dansky (Millennium Pharmaceuticals. Inc.) ; Spigel, David R. (Personal Genome Diagnostics) ; Universitat Autònoma de Barcelona
We assessed the Aurora A kinase inhibitor, alisertib, plus paclitaxel (henceforth referred to as alisertib/paclitaxel) as second-line treatment for SCLC. In this double-blind study, patients with relapsed or refractory SCLC were stratified by relapse type (sensitive versus resistant or refractory) and brain metastases and randomized 1:1 to alisertib/paclitaxel or placebo plus paclitaxel (henceforth referred to as placebo/paclitaxel) in 28-day cycles. [...]
2020 - 10.1016/j.jtho.2019.10.013
Journal of Thoracic Oncology, Vol. 15 Núm. 2 (february 2020) , p. 274-287  
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