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7 p, 1.2 MB C-Terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease / García-Ayllón, María-Salud (Hospital General Universitario de Elche) ; Lopez-Font, Inmaculada (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Boix, Claudia P. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Fortea, Juan (Fundació Catalana Síndrome de Down) ; Sánchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ; Zetterberg, Henrik (University College London) ; Blennow, Kaj (University of Gothenburg) ; Sáez-Valero, Javier (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
This study assesses whether C-Terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal fluid (CSF) and their potential as biomarkers for Alzheimer's disease (AD). Immunoprecipitation and simultaneous assay by Western blotting using multiplex fluorescence imaging with specific antibodies against particular domains served to characterize CTFs of APP in human CSF. [...]
2017 - 10.1038/s41598-017-02841-7
Scientific reports, Vol. 7 Núm. 1 (january 2017) , p. 2477  
Detailed record - Creative Commons

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1 Lopez-Font, I.
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