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18 p, 4.5 MB Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin : Increased Cytotoxicity and Impairment of Cell Migration and Invasion / Manguinhas, Rita (Universidade de Lisboa) ; Fernandes, Ana S. (Universidade Lusófona de Humanidades e Tecnologias, Lisboa) ; Costa, João G. (Universidade Lusófona de Humanidades e Tecnologias, Lisboa) ; Saraiva, Nuno (Universidade Lusófona de Humanidades e Tecnologias, Lisboa) ; Camões, Sérgio P. (Universidade de Lisboa) ; Gil, Nuno (Lung Cancer Unit, Champalimaud Centre for the Unknown, Lisboa) ; Rosell, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Castro, Matilde (Universidade de Lisboa) ; Miranda, Joana P. (Universidade de Lisboa) ; Oliveira, Nuno G. (Universidade de Lisboa)
Elevated expression levels of the apurinic/apyrimidinic endonuclease 1 (APE1) have been correlated with the more aggressive phenotypes and poor prognosis of non-small cell lung cancer (NSCLC). This study aimed to assess the impact of the inhibition of the redox function of APE1 with E3330 either alone or in combination with cisplatin in NSCLC cells. [...]
2020 - 10.3390/antiox9060550
Antioxidants, Vol. 9 (june 2020)  
Detailed record - Creative Commons

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