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33 p, 20.4 MB

Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells / Zhang, Yu Wei (University of Freiburg, Germany) ; Mess, Julian (University of Freiburg, Germany) ; Aizarani, Nadim (University of Freiburg, Germany) ; Mishra, Pankaj (University of Freiburg, Germany) ; Johnson, Carys (University of Cambridge, UK) ; Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ; Rettkowski, Jasmin (University of Freiburg, Germany) ; Schönberger, Katharina (University of Freiburg, Germany) ; Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Woessner, Nadine M. (University of Freiburg, Germany) ; Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Velasco-Hernandez, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sikora, Katarzyna (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Wäsch, Ralph (University of Freiburg, Germany) ; Lehnertz, Bernhard (University of Montreal, Canada) ; Sauvageau, Guy (University of Montreal, Canada) ; Manke, Thomas (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Menendez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ; Walter, Sebastian Gottfried (University Hospital of Cologne, Germany) ; Minguet, Susana (University of Freiburg, Germany) ; Laurenti, Elisa (University of Cambridge, UK) ; Günther, Stefan (University of Freiburg, Germany) ; Grün, Dominic (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ; Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. [...]
2022 - DOI (Digital Object Identifier)

10.1038/s41556-022-00931-x
Nature Cell Biology, Vol. 24 Núm. 7 (july 2022) , p. 1038-1048

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