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17 p, 3.1 MB The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer / Armaos, Alexandros (Istituto Italiano di Tecnologia) ; Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Núñez-Carpintero, Iker (Barcelona Supercomputing Center) ; Seo, J.H.Ji-Heui (Department of Medical Oncology, Dana Farber Cancer Institute (Estats Units d'Amèrica)) ; Baca, Sylvan C. (Department of Medical Oncology, Dana Farber Cancer Institute (Estats Units d'Amèrica)) ; Gustincich, Stefano (Istituto Italiano di Tecnologia) ; Valencia, Alfonso (Institució Catalana de Recerca i Estudis Avançats) ; Freedman, Matthew L. (Broad Institute (Estats Units d'Amèrica)) ; Cirillo, D. (Barcelona Supercomputing Center) ; Giambartolomei, C. (Human Technopol (Itàlia)) ; Tartaglia, G.G. (Istituto Italiano di Tecnologia (Itàlia))
We introduce Promoter-Enhancer-Guided Interaction Networks (PENGUIN), a method for studying protein-protein interaction (PPI) networks within enhancer-promoter interactions. PENGUIN integrates H3K27ac-HiChIP data with tissue-specific PPIs to define enhancer-promoter PPI networks (EPINs). [...]
2023 - 10.1038/s41467-023-43767-1
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 8084  
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