Nizetic, Dean - Resultats de la cerca - Dipòsit Digital de Documents de la UAB

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12 p, 1.2 MB

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease / Startin, Carla M. (LonDownS Consortium (London Down Syndrome Consortium)) ; Ashton, Nicholas J. (University of Gothenburg) ; Hamburg, Sarah (LonDownS Consortium (London Down Syndrome Consortium)) ; Hithersay, Rosalyn (LonDownS Consortium (London Down Syndrome Consortium)) ; Wiseman, Frances K. (University College London) ; Mok, Kin Y. (Hong Kong University of Science and Technology) ; Hardy, John (University College London) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Lovestone, Simon (University of Oxford) ; Parnetti, Lucilla (University of Perugia) ; Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ; Hye, Abdul (Maudsley NHS Foundation) ; Fisher, Elisabeth ; Nizetic, Dean ; Tybulewicz, Victor ; Karmiloff-Smith, Anette ; Al-Janabi, Tamara ; Zhang, David ; Strydom, André (LonDownS Consortium (London Down Syndrome Consortium)) ; Universitat Autònoma de Barcelona
Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with sporadic AD (sAD) without DS, and controls will aid in understanding AD development in DS. [...]
2019 - DOI (Digital Object Identifier)

10.1186/s13195-019-0477-0
Alzheimer's research & therapy, Vol. 11 Núm. 1 (21 2019) , p. 26

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