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8 p, 1.0 MB |
Plain language summary of the MajesTEC-1 study of teclistamab for the treatment of people with relapsed or refractory multiple myeloma
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Moreau, Philippe (University Hospital Hôtel-Dieu) ;
Van De Donk, Niels WCJ (Department of Hematology. Amsterdam University Medical Center) ;
Nahi, Hareth (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Nooka, Ajay K (Winship Cancer Institute. Emory University) ;
Martin, Thomas (University of California San Francisco) ;
Rosinol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Karlin, Lionel (Centre Hospitalier Lyon Sud) ;
Benboubker, Lotfi (Hôpital Bretonneau) ;
Mateos, Maria-Victoria (University Hospital de Salamanca) ;
Popat, Rakesh (University College London Hospitals) ;
Martínez-López, Joaquín (Hospital Universitario 12 de Octubre (Madrid)) ;
Sidana, Surbhi (Stanford University of Medicine) ;
Delforge, Michele (University of Leuven) ;
Pei, Lixia (Janssen Research & Development) ;
Trancucci, Danielle (Janssen Research & Development) ;
Olyslager, Yunsi (Janssen Research & Development) ;
Uhlar, Clarissa (Janssen Research & Development) ;
Stephenson, Tara (Janssen Research & Development) ;
Rampelbergh, Rian Van (Janssen Research & Development) ;
Banerjee, Arnob (Janssen Research & Development) ;
Kobos, Rachel (Janssen Research & Development) ;
Usmani, Saad Z (Levine Cancer Institute-Atrium Health)
What is this summary about? This is a summary of a phase 1-2 clinical trial called MajesTEC-1. This trial tested the cancer drug teclistamab in people with relapsed or refractory multiple myeloma, a cancer that forms in a certain type of white blood cells known as plasma cells. [...]
2023 -  10.2217/fon-2023-0171
Future oncology (London, England), Vol. 19 Núm. 12 (january 2023) , p. 811-818
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9 p, 603.3 KB |
Teclistamab Improves Patient-Reported Symptoms and Health-Related Quality of Life in Relapsed or Refractory Multiple Myeloma : Results From the Phase II MajesTEC-1 Study
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Martin, Thomas G. (University of California San Francisco, USA) ;
Moreau, Philippe (University Hospital Hôtel-Dieu, Nantes, France) ;
Usmani, Saad Z. (Levine Cancer Institute/Atrium Health, Charlotte, NC) ;
Garfall, Alfred (University of Pennsylvania, Philadelphia, PA) ;
Mateos, M. V (Hospital Universitario de Salamanca) ;
San-Miguel, Jesús F. (Clínica Universidad de Navarra) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Nooka, Ajay K. (Emory University, Atlanta, GA) ;
Rosiñol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Chari, Ajay (Mount Sinai School of Medicine, New York, USA) ;
Karlin, Lionel (Centre Hospitalier Lyon Sud, Pierre-Bénite, France) ;
Krishnan, Amrita (City of Hope National Medical Center (Duarte, Estats Units d'Amèrica)) ;
Bahlis, Nizar (University of Calgary, Canada) ;
Popat, Rakesh (University College London) ;
Besemer, Britta (University of Tuebingen, Tuebingen, Germany) ;
Martínez-López, Joaquín (Hospital Universitario 12 de Octubre (Madrid)) ;
Delforge, Michel (Universitaire Ziekenhuizen Leuven, Belgium) ;
Trancucci, Danielle (Janssen Research & Development, Raritan, NJ) ;
Pei, Lixia (Janssen Research & Development, Raritan, NJ) ;
Kobos, Rachel (Janssen Research & Development, Raritan, NJ) ;
Fastenau, John (Janssen Research & Development, Raritan, NJ) ;
Gries, Katharine S. (Janssen Research & Development, Raritan, NJ) ;
van de Donk, Niels W.C.J. (Amsterdam University Medical Center, Vrije Universiteit Amsterdam, The Netherlands)
Introduction: Patients with relapsed or refractory multiple myeloma (RRMM) report significantly lower HRQoL compared with patients with newly diagnosed MM and experience further deterioration in HRQoL with each relapse and subsequent treatment. [...]
2023 - 10.1016/j.clml.2023.11.001
Clinical Lymphoma, Myeloma & Leukemia, 2023
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14 p, 1.3 MB |
Spleen tyrosine kinase/FMS-like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma : updated data with mivavotinib (TAK-659/CB-659)
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Gordon, Leo I. (Northwestern University Feinberg School of Medicine) ;
Karmali, Reem (Northwestern University Feinberg School of Medicine) ;
Kaplan, Jason B. (Northwestern University Feinberg School of Medicine) ;
Popat, Rakesh (University College London) ;
Burris, Howard A. (Sarah Cannon Research Institute/Tennessee Oncology) ;
Ferrari, Silvia (Ospedale Papa Giovanni XXIII) ;
Madan, Sumit (Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USA) ;
Patel, Manish R. (Florida Cancer Specialists/Sarah Cannon Research Institute) ;
Gritti, Giuseppe (Ospedale Papa Giovanni XXIII) ;
El-Sharkawi, Dima (Royal Marsden Hospital (Regne Unit)) ;
Chau, F. Ian (Royal Marsden Hospital (Regne Unit)) ;
Radford, John (University of Manchester) ;
de Oteyza, Jaime Pérez (Hospital Universitario HM Sanchinarro (Madrid)) ;
Zinzani, Pier Luigi (Università di Bologna) ;
Iyer, Swaminathan P. (University of Texas MD Anderson Cancer Center) ;
Townsend, William (University College London Hospitals) ;
Miao, Harry (Takeda Development Center Americas) ;
Proscurshim, Igor (Takeda Development Center Americas) ;
Wang, Shining (Takeda Development Center Americas) ;
Katyayan, Shilpi (Labcorp Drug Development (Estats Units d'Amèrica)) ;
Yuan, Ying (Takeda Development Center Americas) ;
Zhu, Jiaxi (Takeda Development Center Americas) ;
Stumpo, Kate (Takeda Development Center Americas) ;
Shou, Yaping (Takeda Development Center Americas) ;
Carpio Segura, Cecilia del Carmen (Vall d'Hebron Institut d'Oncologia) ;
Bosch José, Francesc Xavier 1947- (Universitat Autònoma de Barcelona)
We report an updated analysis from a phase I study of the spleen tyrosine kinase (SYK) and FMS-like tyrosine kinase 3 inhibitor mivavotinib, presenting data for the overall cohort of lymphoma patients, and the subgroup of patients with diffuse large B-cell lymphoma (DLBCL; including an expanded cohort not included in the initial report). [...]
2023 - 10.18632/oncotarget.28352
Oncotarget, Vol. 14 (january 2023) , p. 57-70
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15 p, 1.2 MB |
First-in-Human Phase I Study of Iadademstat (ORY-1001) : A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia
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Salamero, Olga (Vall d'Hebron Institut d'Oncologia) ;
Montesinos, Pau (Centro de Investigación Biomédica en Red de Cáncer) ;
Willekens, Christophe (Institut Gustave Roussy (Villejuif, França)) ;
Pérez-Simón, José Antonio (Universidad de Sevilla) ;
Pigneux, Arnaud (Centre Hospitalier Universitaire CHU Bordeaux) ;
Récher, Christian (Hospitalier Universitaire de Toulouse) ;
Popat, Rakesh (University College London) ;
Carpio Segura, Cecilia del Carmen (Vall d'Hebron Institut d'Oncologia) ;
Molinero, César (Parc Científic de Barcelona. Oryzon Genomics) ;
Mascaró, Cristina (Parc Científic de Barcelona. Oryzon Genomics) ;
Vila, Joaquim (Parc Científic de Barcelona. Oryzon Genomics) ;
Arévalo, M. Isabel (Parc Científic de Barcelona. Oryzon Genomics) ;
Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics) ;
Buesa, Carlos (Parc Científic de Barcelona. Oryzon Genomics) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
Somervaille, Tim (The University of Manchester) ;
Universitat Autònoma de Barcelona
This phase I, nonrandomized, open-label, dose-escalation (DE), and extension-cohort (EC) trial included patients with R/R AML and evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antileukemic activity of this orally bioavailable first-in-class lysine-specific demethylase 1 inhibitor. [...]
2020 - 10.1200/JCO.19.03250
Journal of Clinical Oncology, Vol. 38 (october 2020) , p. 4260-4273
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