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9 p, 526.0 KB |
Burden of refractory and unexplained chronic cough on patients' lives : a cohort study
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Puente, Luis (=)) ;
Dávila, Ignacio (Hospital Clínico Universitario (Salamanca)) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Crespo Lessmann, Astrid (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
Sola, Javier (Hospital Universitario Ramón y Cajal (Madrid)) ;
Nieto, María Luisa (Hospital Arnau de Vilanova (València)) ;
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela) ;
Cea-Calvo, Luis (Medical Affairs) ;
Sánchez-Jareño, Marta (Medical Affairs) ;
Rivas-Pardinas, Cristina (Medical Affairs) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona
Chronic cough (cough lasting for ≥8 weeks) can lead to significant impairment in quality of life (QoL). Using patient-reported outcomes, this cohort study assessed the perceived impact of chronic cough on QoL and everyday life in patients from outpatient hospital clinics with refractory chronic cough (RCC) or unexplained chronic cough (UCC). [...]
2023 -  10.1183/23120541.00425-2023
ERJ Open Research, Vol. 9 (september 2023)
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2.
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22 p, 279.7 KB |
Identificación de las carencias asistenciales en la atención clínica del asma en España : resultados de la encuesta OPTIMA-GEMA
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Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Rodriguez del Rio, Pablo (Hospital Niño Jesús (Madrid)) ;
Gómez Ruiz, Fernando (Centro de Salud de Bargas (Toledo)) ;
López Viña, Antolín (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Molina París, Jesús (EAP Francia I (Fuenlabrada, Madrid)) ;
Quintano Jiménez, José Antonio (Centro de Salud Lucena (Córdoba)) ;
Quirce Gancedo, Santiago (Fundación para la Investigación Biomédica del Hospital Universitario La Paz) ;
Soler Vilarrasa, Ramona (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Villa Asensi, José Ramón (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Nieto Garcíá, Antonio (Hospital Universitari i Politècnic La Fe (València))
Fundamento. En línea con el lanzamiento de la guía GEMA2009, el objetivo del estudio fue identificar y evaluar las carencias en la implementación de las recomendaciones de la misma y proponer iniciativas de mejora. [...]
Background: Based on the GEMA 2009 guidelines (Spanish Asthma Management Guidelines), this project identified and assessed the main deficiencies in the implementation of the guidelines and proposed initiatives for improvement. [...]
2016 - 10.23938/ASSN.0274
Anales del sistema sanitario de Navarra, Vol. 39 Núm. 2 (2016) , p. 181-201
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3.
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6 p, 251.2 KB |
How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
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Betancor, Diana (Hospital Universitario Fundación Jiménez Díaz) ;
Olaguibel, José María (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodrigo-Muñoz, José Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Arismendi, Ebymar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Barranco, Pilar (Hospital Universitario La Paz (Madrid)) ;
Barroso, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Bobolea, Irina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cárdaba, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Cruz, María Jesús (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Del Pozo, Victoria (Hospital Universitario Fundación Jiménez Díaz) ;
González-Barcala, Francisco-Javier (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mullol, Joaquim (Universitat de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Picado, Cesar (Universitat de Barcelona) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Rial, Manuel Jorge (Complejo Hospitalario Universitario de A Coruña) ;
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valverde-Monge, Marcela (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Sastre, Joaquin (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. [...]
2022 - 10.1002/clt2.12182
Clinical and translational allergy, Vol. 12, Issue 8 (August 2022) , art. e12182
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4.
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17 p, 1.5 MB |
Multi-ancestry genome-wide association study of asthma exacerbations
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Herrera-Luis, Esther (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Ortega, Victor E. (División de Medicina Respiratoria. Departamento de Medicina Interna. Mayo Clinic) ;
Ampleford, Elizabeth J. (Department of Internal Medicine. Center for Precision Medicine. Wake Forest School of Medicine) ;
Sio, Yang Yie (Department of Biological Sciences. National University of Singapore) ;
Granell, Raquel (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
de Roos, Emmely (Department of Respiratory Medicine. Ghent University Hospital) ;
Terzikhan, Natalie (Department of Respiratory Medicine. Ghent University Hospital) ;
Vergara, Ernesto Elorduy (Institute of Computation Biology. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Hernandez-Pacheco, Natalia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Perez-Garcia, Javier (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Martin-Gonzalez, Elena (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Lorenzo-Diaz, Fabian (Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias. Universidad de La Laguna) ;
Hashimoto, Simone (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Brinkman, Paul (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Jorgensen, Andrea L. (Department of Health Data Science. Institute of Population Health. University of Liverpool) ;
Yan, Qi (Department of Obstetrics and Gynecology. Columbia University Irving Medical Center) ;
Forno, Erick (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Vijverberg, Susanne J. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
Lethem, Ryan (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
Espuela-Ortiz, Antonio (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Gorenjak, Mario (Center for Human Molecular Genetics and Pharmacogenomics. Faculty of Medicine. University of Maribor) ;
Eng, Celeste (Department of Medicine. University of California San Francisco) ;
González-Pérez, Ruperto (Unidad de Asma Grave. Servicio de Alergología. Hospital Universitario de Canarias.) ;
Hernández-Pérez, José M. (Hospital General de La Palma. Servicio de Neumología) ;
Poza-Guedes, Paloma (Hospital Universitario de Canarias. Unidad de Asma Grave. Servicio de Alergología) ;
Sardón, Olaia (Universidad del País Vasco. Departamento de Pediatría) ;
Corcuera, Paula (Hospital Universitario Donostia. Division of Pediatric Respiratory Medicine) ;
Hawkins, Greg A. (Department of Biochemistry. Wake Forest School of Medicine) ;
Marsico, Annalisa (Computational Health Center. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Bahmer, Thomas (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Rabe, Klaus F. (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Hansen, Gesine (Department of Pediatric Pneumology. Allergology and Neonatology. Hannover Medical School) ;
Kopp, Matthias V. (Department of Paediatric Respiratory Medicine. Inselspital. University Children's Hospital of Bern. University of Bern) ;
Rios, Raimon (Programa de Pós Graduação em Imunologia (PPGIm). Instituto de Ciências da Saúde. Universidade Federal da Bahia (UFBA)) ;
Cruz, Maria Jesús (Hospital Universitari Vall d'Hebron) ;
González-Barcala, Francisco Javier (Complejo Hospitalario Universitario de Santiago de Compostela. Servicio de Neumología) ;
Olaguibel, José María (Complejo Hospitalario de Navarra) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz. Instituto de Investigación Hospital Universitario La Paz. Servicio de Alergología) ;
Canino, Glorisa (Behavioral Sciences Research Institute. University of Puerto Rico) ;
Cloutier, Michelle (Department of Pediatrics. University of Connecticut) ;
Del Pozo, Victoria (Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz. Servicio de Inmunología) ;
Rodriguez-Santana, Jose R. (Centro de Neumología Pediátrica) ;
Korta-Murua, Javier (Universidad del País Vasco. Departamento de Pediatría) ;
Villar, Jesús (Hospital Universitario de Gran Canaria Doctor Negrín. Multidisciplinary Organ Dysfunction Evaluation Research Network. Research Unit) ;
Potočnik, Uros (Laboratory for Biochemistry. Molecular Biology and Genomics. Faculty for Chemistry and Chemical Engineering. University of Maribor) ;
Figueiredo, Camila (Instituto de Ciências da Saúde. Universidade Federal da Bahia) ;
Kabesch, Michael (Department of Paediatric Pneumology and Allergy. University Children's Hospital Regensburg (KUNO)) ;
Mukhopadhyay, Somnath (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Pirmohamed, Munir (Department of Pharmacology and Therapeutics. Institute of Systems. Molecular and Integrative Biology. University of Liverpool) ;
Hawcutt, Daniel (NIHR Alder Hey Clinical Research Facility. Alder Hey Children's Hospital) ;
Melén, Erik (Sachs' Children's Hospital. South General Hospital) ;
Palmer, Colin (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Turner, Steve (Child Health. University of Aberdeen) ;
Maitland-van der Zee, Anke H. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
von Mutius, Erika (Comprehensive Pneumology Center Munich (CPC-M). Member of the German Center for Lung Research) ;
Celedón, Juan C. (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Brusselle, Guy (Department of Respiratory Medicine. Erasmus University Medical Center) ;
Chew, Fook Tim (Department of Biological Sciences. National University of Singapore) ;
Bleecker, Eugene (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Meyers, Deborah (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Burchard, Esteban G. (Department of Bioengineering and Therapeutic Sciences. University of California San Francisco) ;
Pino-Yanes, Maria (Universidad de la Laguna. Instituto de Tecnologías Biomédicas)
Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. [...]
2022 - 10.1111/pai.13802
Pediatric Allergy and Immunology, Vol. 33 Núm. 6 (june 2022) , p. e13802
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4 p, 199.7 KB |
Work-related dysphonia in subjects with occupational asthma is associated with neutrophilic airway inflammation
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Migueres, Nicolas (Strasbourg University) ;
Vandenplas, Olivier (Université Catholique de Louvain) ;
Walusiak-Skorupa, Jolanta (Nofer Institute of Occupational Medicine) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Suojalehto, Hille (Finnish Institute of Occupational Health) ;
van Kampen, Vera (Ruhr University) ;
Mason, Paola (University of Padova) ;
Quirce Gancedo, Santiago (IdiPAZ and CIBER de Enfermedades Respiratorias (CIBERES)) ;
de Blay, Frédéric (Strasbourg University) ;
Universitat Autònoma de Barcelona
2023 - 10.1002/clt2.12218
Clinical and translational allergy, Vol. 13 (may 2023)
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12 p, 608.0 KB |
Characteristics and Management of Patients with Refractory or Unexplained Chronic Cough in Outpatient Hospital Clinics in Spain : A Retrospective Multicenter Study
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Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Dávila, Ignacio (Universidad de Salamanca) ;
Puente, Luis (Hospital General Universitario Gregorio Marañón) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona) ;
Díaz Palacios, Miguel (Hospital Universitari i Politècnic La Fe (València)) ;
Pereira-Vega, Antonio (Hospital Juan Ramón Jiménez (Huelva)) ;
De Diego, Alfredo (Hospital Universitari i Politècnic La Fe (València)) ;
Rodriguez Hermosa, Juan Luis (Universidad Complutense de Madrid) ;
Cea-Calvo, Luis (MSD España) ;
Sánchez Jareño, Marta (MSD España) ;
López Cotarelo, Pilar (MSD España) ;
Universitat Autònoma de Barcelona
Purpose: Chronic cough (cough that persists for ≥ 8 weeks) can cause a range of physical symptoms and psychosocial effects that significantly impair patients' quality of life. Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are challenging to diagnose and manage, with substantial economic implications for healthcare systems. [...]
Springer New York, 2023 - 10.1007/s00408-023-00620-y
Lung
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14 p, 2.6 MB |
Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids
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Gil-Martínez, Marta (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Lorente-Sorolla, Clara (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Rodrigo-Muñoz, José M. (Instituto de Salud Carlos III) ;
Lendínez, Miguel Ángel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Núñez-Moreno, Gonzalo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
de la Fuente, Lorena (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mínguez, Pablo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mahíllo-Fernández, Ignacio (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz) ;
Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Caballero, María L. (Hospital Universitario La Paz (Madrid)) ;
González-Barcala, Francisco J. (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ;
Valero, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Cruz, María Jesús (Hospital Universitari Vall d'Hebron) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Olaguibel, José M. (Complejo Hospitalario de Navarra) ;
Del Pozo, Victoria (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. [...]
2023 - 10.3390/ijms24021611
International journal of molecular sciences, Vol. 24 (january 2023)
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10 p, 933.3 KB |
Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
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Rial, Manuel J. (Hospital Universitario Fundación Jiménez Díaz) ;
Álvarez-Puebla, Maria J. (Complejo Hospitalario de Navarra) ;
Arismendi, Ebymar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Caballero, María L. (Hospital Universitario La Paz (Madrid)) ;
Cañas, José A. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Cruz Carmona, María Jesús (Hospital Universitari Vall d'Hebron) ;
González-Barcala, Francisco-Javier (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Luna-Porta, Juan-Alberto (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mullol, Joaquim (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Olaguibel, José M. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Picado, César (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Romero-Mesones, Christian (Hospital Universitari Vall d'Hebron) ;
Salgado, Francisco-Javier (Universidade de Santiago de Compostela) ;
Sastre, Beatriz (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valverde, Marcela (Hospital Universitario Fundación Jiménez Díaz) ;
Sastre, Joaquin (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Del Pozo, Victoria (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Universitat Autònoma de Barcelona
The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder. [...]
2021 - 10.1002/clt2.12001
Clinical and translational allergy, Vol. 11 (march 2021)
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9 p, 537.0 KB |
Efficacy and Safety of Reslizumab in Patients with Severe Asthma with Inadequate Response to Omalizumab : A Multicenter, Open-Label Pilot Study
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Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Cosio, Borja G. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Domingo, Christian (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Urrutia, Isabel (Hospital de Galdakao (Usansolo, Biscaia)) ;
Bobolea, Irina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Entrenas Costa, Luis M. (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Barranco, Pilar (Hospital Universitario La Paz (Madrid)) ;
Marina Malanda, Nuria (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Prieto Andrés, Luis (Hospital Universitari Doctor Peset (València)) ;
Alvarez-Gutiérrez, Francisco J. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Background: Patients with severe allergic and eosinophilic asthma could qualify for different biologic therapies. Objective: To evaluate the efficacy and safety of weight-based intravenous reslizumab dosing in patients who have previously failed therapy with omalizumab. [...]
2019 - 10.1016/j.jaip.2019.01.017
The Journal of allergy and clinical immunology. In practice, Vol. 7 Núm. 7 (september 2019) , p. 2277-2283.e2
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