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13 p, 3.0 MB Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q / Ademà, Vera (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Walter, Wencke (Munich Leukemia Laboratory) ; Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hutter, Stephan (Munich Leukemia Laboratory) ; La Framboise, Thomas (Department of Genetics and Genome Sciences. Case Western Reserve University) ; Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ; Meggendorfer, Manja (Munich Leukemia Laboratory) ; Radivoyevitch, Tomas (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pellagatti, Andrea (Blood Cancer UK Molecular Haematology Unit. Nuffield Division of Clinical Laboratory Sciences. Radcliffe Department of Medicine. University of Oxford and Oxford BRC Haematology Theme) ; Haferlach, Claudia (Munich Leukemia Laboratory) ; Boultwood, Jacqueline (University of Oxford. Radcliffe Department of Medicine) ; Kern, Wolfgang (Munich Leukemia Laboratory) ; Visconte, Valeria (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ; Sekeres, Mikkael (Leukemia Program. Department of Hematology and Medical Oncology. Cleveland Clinic. Cleveland Clinic Taussig Cancer Institute) ; Barnard, John (Department of Quantitative Health Sciences. Cleveland Clinic. Lerner Research Institute) ; Haferlach, Torsten (Munich Leukemia Laboratory) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Maciejewski, Jaroslaw (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute)
Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of del(5q) have not been yet clarified. [...]
2022 - 10.1016/j.ebiom.2022.104059
EBioMedicine, Vol. 80 (june 2022) , art. 104059  
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