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9 p, 1.3 MB Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase / Stevens, Emily (Milner Centre for Evolution, Dept. of Biology and Biochemistry, University of Bath) ; Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gardner, Stewart (School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln) ; Somerville, Greg A. (School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln) ; Massey, Ruth C. (School of Molecular and Cellular Medicine, University of Bristol) ; Universitat Autònoma de Barcelona
Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase signal independent of Agr. [...]
2017 - 10.1038/s41598-017-14110-8
Scientific reports, Vol. 7 (october 2017)  
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