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1.
8 p, 1.1 MB Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity / Chatterjee, Shambhabi (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ; Derda, Anselm Arthur (Hannover Medical School. Department of Cardiology and Angiology) ; Schimmel, Katharina (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Sonnenschein, Kristina (Hannover Medical School. Department of Cardiology and Angiology) ; Bavendiek, Udo (Hannover Medical School. Department of Cardiology and Angiology) ; Bauersachs, Johann (REBIRTH Excellence Cluster. Hannover Medical School) ; Bär, Christian (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Thum, Thomas (National Heart and Lung Institute. Imperial College London)
Telomere length is a marker of biological aging. Short leukocyte telomere length has been associated with various conditions including cardiovascular disorders. Here, we evaluated if patients with hypertrophic cardiomyopathy have altered leukocyte telomere length and whether this is associated with disease severity. [...]
2018 - 10.1038/s41598-018-29072-8
Scientific reports, Vol. 8 Núm. 1 (january 2018) , p. 11227  
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2.
8 p, 1.1 MB Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy / Sonnenschein, Kristina (Hannover Medical School. Department of Cardiology and Angiology) ; Wilczek, Adriana Luisa (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ; Pfanne, Angelika (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Derda, Anselm Arthur (Hannover Medical School. Department of Cardiology and Angiology) ; Zwadlo, Carolin (Hannover Medical School. Department of Cardiology and Angiology) ; Bavendiek, Udo (Hannover Medical School. Department of Cardiology and Angiology) ; Bauersachs, Johann (REBIRTH Center of Translational Regenerative Medicine. Hannover Medical School) ; Fiedler, Jan (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Thum, Thomas (REBIRTH Center of Translational Regenerative Medicine. Hannover Medical School)
Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and is associated with a high risk of sudden cardiac death. HCM is characterized by pronounced hypertrophy of cardiomyocytes, fiber disarray and development of fibrosis and can be divided into a non-obstructive (HNCM) and obstructive form (HOCM) therefore requiring personalized therapeutic therapies. [...]
2019 - 10.1038/s41598-019-56617-2
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 20350  
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