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8 p, 1.1 MB Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy / Sonnenschein, Kristina (Hannover Medical School. Department of Cardiology and Angiology) ; Wilczek, Adriana Luisa (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau) ; Pfanne, Angelika (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Derda, Anselm Arthur (Hannover Medical School. Department of Cardiology and Angiology) ; Zwadlo, Carolin (Hannover Medical School. Department of Cardiology and Angiology) ; Bavendiek, Udo (Hannover Medical School. Department of Cardiology and Angiology) ; Bauersachs, Johann (REBIRTH Center of Translational Regenerative Medicine. Hannover Medical School) ; Fiedler, Jan (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School) ; Thum, Thomas (REBIRTH Center of Translational Regenerative Medicine. Hannover Medical School)
Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and is associated with a high risk of sudden cardiac death. HCM is characterized by pronounced hypertrophy of cardiomyocytes, fiber disarray and development of fibrosis and can be divided into a non-obstructive (HNCM) and obstructive form (HOCM) therefore requiring personalized therapeutic therapies. [...]
2019 - 10.1038/s41598-019-56617-2
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 20350  

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