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Artículos, Encontrados 3 registros

Artículos	Encontrados 3 registros

18 p, 9.8 MB

Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses / Rodríguez-Ubreva, J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Arutyunyan, A. (University of Cambridge) ; Bonder, M.J. (German Cancer Research Center) ; Del Pino-Molina, L. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Clark, S.J. (Babraham Institute) ; de la Calle-Fabregat, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ; Garcia-Alonso, L. (CeWellcome Sanger Institute) ; Handfield, L.F. (Wellcome Trust Sanger Institute (Regne Unit)) ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Krueger, F. (Babraham Institute) ; Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Rodríguez-Cortez, V.C. (Institut d'Investigació Biomèdica de Bellvitge) ; Polanski, K. (Wellcome Trust Sanger Institute (Regne Unit)) ; Mamanova, L. (Wellcome Trust Sanger Institute (Regne Unit)) ; van Dongen, S. (Wellcome Trust Sanger Institute (Regne Unit)) ; Kiselev, V.Y. (Wellcome Trust Sanger Institute (Regne Unit)) ; Martínez-Saavedra, M.T. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Heyn, Holger (Universitat Pompeu Fabra) ; Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ; Warnatz, K. (University of Freiburg) ; López-Granados, E. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Rodríguez-Gallego, C. (University Fernando Pessoa) ; Stegle, O. (Wellcome Trust Sanger Institute (Regne Unit)) ; Kelsey, G. (Babraham Institute) ; Vento Tormo, Roser (University of Cambridge) ; Ballestar, Esteban (East China Normal University) ; Universitat Autònoma de Barcelona
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and ample phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. [...]
2022 - DOI (Digital Object Identifier)

10.1038/s41467-022-29450-x
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 1779

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17 p, 5.1 MB

Robust temporal map of human in vitro myelopoiesis using single-cell genomics / Alsinet, Clara (Open Targets. Wellcome Genome Campus) ; Primo, Maria Nascimento (Open Targets. Wellcome Genome Campus) ; Lorenzi, Valentina (Wellcome Sanger Institute. Wellcome Genome Campus) ; Bello, Erica (Open Targets. Wellcome Genome Campus) ; Kelava, Iva (Wellcome Sanger Institute. Wellcome Genome Campus) ; Jones, Carla P. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Vilarrasa Blasi, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ; Sancho Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ; Knights, Andrew J. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Park, Jong Eun (Korea Advanced Institute of Science and Technology) ; Wyspianska, Beata S. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ; Trynka, Gosia (Open Targets. Wellcome Genome Campus) ; Tough, David F. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ; Bassett, Andrew (Open Targets. Wellcome Genome Campus) ; Gaffney, Daniel J. (Wellcome Sanger Institute. Wellcome Genome Campus) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vento Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus)
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis protocols is imperative for their use in research, immunotherapies, and understanding human myelopoiesis. Here, we generate a >470K cells molecular map of human induced pluripotent stem cells (iPSC) differentiation into macrophages. [...]
2022 - DOI (Digital Object Identifier)

10.1038/s41467-022-30557-4
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2885

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22 p, 5.6 MB

Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines / Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Barmada, Anis (University of Cambridge. Department of Medical Genetics) ; Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martins-Ferreira, Ricardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ferreté-Bonastre, Anna G. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ruiz-Sanmartín, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina) ; Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron) ; Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina) ; Ruiz-Rodriguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ; Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vento-Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus, Hinxton, UK) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. [...]
2022 - DOI (Digital Object Identifier)

10.1186/s13073-022-01137-4
Genome Medicine, Vol. 14 (november 2022)

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