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14 p, 1.1 MB Imaging Response to Contemporary Immuno-oncology Combination Therapies in Patients With Metastatic Renal Cell Carcinoma / Navani, Vishal (University of Calgary) ; Ernst, Matthew (University of Calgary) ; Wells, J. Connor (BC Cancer Agency) ; Yuasa, Takeshi (Japanese Foundation for Cancer Research) ; Takemura, Kosuke (Japanese Foundation for Cancer Research) ; Donskov, Frede (Aarhus University Hospital (Aarhus, Dinamarca)) ; Basappa, Naveen S. (University of Alberta) ; Schmidt, Andrew (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Pal, Sumanta K. (City of Hope Comprehensive Cancer Center) ; Meza, Luis (City of Hope Comprehensive Cancer Center) ; Wood, Lori A. (Queen Elizabeth II Health Sciences Centre) ; Ernst, D. Scott (London Regional Cancer Centre) ; Szabados, Bernadett (Queen Mary University of London) ; Powles, Thomas (Queen Mary University of London) ; McKay, Rana R. (University of California) ; Weickhardt, Andrew (Olivia Newton-John Cancer and Wellness Centre) ; Suárez, Cristina (Hospital Universitari Vall d'Hebron) ; Kapoor, Anil (McMaster University (Canadà)) ; Lee, Jae Lyun (University of Ulsan College of Medicine) ; Choueiri, Toni K. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Heng, Daniel Y. C. (University of Calgary) ; Universitat Autònoma de Barcelona
Do contemporary first-line therapy options for metastatic renal cell carcinoma (mRCC) have different likelihoods of objective imaging response (complete or partial response), and is objective imaging response associated with overall survival? In this cohort study involving 899 patients with mRCC, treatment with immune checkpoint blockade plus vascular endothelial growth factor receptor inhibitor combination therapies was more likely to be associated with objective imaging response than doublet immune checkpoint blockade therapy after adjustment for baseline demographic and clinical characteristics, including International Metastatic Renal Cell Carcinoma Database Consortium risk criteria. [...]
2022 - 10.1001/jamanetworkopen.2022.16379
JAMA network open, Vol. 5 (june 2022)  
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