Results overview: Found 2 records in 0.03 seconds.
Articles, 2 records found
Articles 2 records found  
1.
25 p, 24.0 MB AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer / Muñoz-Lorente, Miguel A. (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Martínez, Paula (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Tejera, Águeda (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Whittemore, Kurt (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Moisés-Silva, Ana Carolina (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO)) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco, María A. (Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO))
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. [...]
2018 - 10.1371/journal.pgen.1007562
PLoS Genetics, Vol. 14 (august 2018)  
2.
16 p, 2.7 MB Gene therapy with the 1 telomere gene rescues decreased 1 levels with aging and prolongs mouse health span / Derevyanko, Aksinya (Spanish National Cancer Centre (CNIO)) ; Whittemore, Kurt (Spanish National Cancer Centre (CNIO)) ; Schneider, Ralph P. (Spanish National Cancer Centre (CNIO)) ; Jiménez, Verónica (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Bosch, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Blasco, María A. (Spanish National Cancer Centre (CNIO))
The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand breaks. 1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. [...]
2017 - 10.1111/acel.12677
Aging Cell, Vol. 16 (september 2017) , p. 1353-1368  

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