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Resultados globales: 3 registros encontrados en 0.01 segundos.
Artículos, Encontrados 3 registros
Artículos Encontrados 3 registros  
1.
21 p, 4.8 MB Different Structures-Similar Effect : Do Substituted 5-(4-Methoxyphenyl)-1 H -indoles and 5-(4-Methoxyphenyl)-1 H -imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? / Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry) ; Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Department of Biochemistry) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. [...]
2023 - 10.3390/molecules28145418
Molecules, Vol. 28, Issue 14 (July 2023) , art. 5418  
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2.
29 p, 3.4 MB N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs : Mechanism of Action / Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Shafiullina, Rania (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Kakularam, Kumar R. (University Medicine Berlin. Department of Biochemistry, Charité) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (University Medicine Berlin. Department of Biochemistry, Charité) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Here, we describe the first systematic study on the mechanism of substrate-selective inhibition of mammalian ALOX15 orthologs. For this purpose, we prepared a series of N-substituted 5-(1H-indol-2-yl)anilines and found that (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates and their monofluorinated analogues are potent and selective inhibitors of the linoleate oxygenase activity of rabbit and human ALOX15. [...]
2022 - 10.1021/acs.jmedchem.1c01563
Journal of Medicinal Chemistry, Vol. 65, Issue 3 (February 2022) , p. 1979-1995  
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3.
18 p, 31.6 MB Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15 / Ivanov, Igor (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Zhuravlev, Alexander (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Di Venere, Almerinda (University of Tor Vergata. Department of Experimental Medicine) ; Nicolai, Eleonora (University of Tor Vergata. Department of Experimental Medicine) ; Stehling, Sabine (Charite-University Medicine Berlin. Institute of Biochemistry) ; Osca Lluch, José María (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Institute of Biochemistry)
Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. [...]
2021 - 10.3390/ijms22063285
International journal of molecular sciences, Vol. 22, Issue 6 (March 2021) , art. 3285  
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Vea también: autores con nombres similares
1 Zhuravlev, Andrey V.
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