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14 p, 3.0 MB The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia / Sun, Clare (Hematology Branch. National Heart. Lung. and Blood Institute. National Institutes of Health, Bethesda) ; Chen, Yun Ching (Bioinformatics and Computational Biology Core. National Heart. Lung. and Blood Institute. National Institutes of Health, Bethesda) ; Zurita, Aina Martinez (Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA) ; Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pittaluga, Stefania (Laboratory of Pathology. National Cancer Institute. National Institutes of Health, Bethesda) ; Liu, Delong (Bioinformatics and Computational Biology Core. National Heart. Lung. and Blood Institute. National Institutes of Health, Bethesda) ; Rosebrock, Daniel (Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge MA) ; Gohil, Satyen Harish (University College London) ; Saba, Nakhle S. (Tulane University, New Orleans, LA) ; Davies-Hill, Theresa (Laboratory of Pathology. National Cancer Institute. National Institutes of Health, Bethesda) ; Herman, Sarah E.M. (Hematology Branch. National Heart. Lung. and Blood Institute. National Institutes of Health, Bethesda) ; Getz, Gad (Harvard Medical School, Boston, MA) ; Pirooznia, Mehdi (Bioinformatics and Computational Biology Core. National Heart. Lung. and Blood Institute. National Institutes of Health, Bethesda) ; Wu, Catherine J. (Department of Medicine. Brigham and Women's Hospital, Boston, MA) ; Wiestner, Adrian (Hematology Branch. National Heart. Lung. and Blood Institute. National Institutes of Health, Bethesda)
In chronic lymphocytic leukemia (CLL), B-cell receptor signaling, tumor-microenvironment interactions, and somatic mutations drive disease progression. To better understand the intersection between the microenvironment and molecular events in CLL pathogenesis, we integrated bulk transcriptome profiling of paired peripheral blood (PB) and lymph node (LN) samples from 34 patients. [...]
2023 - 10.1182/bloodadvances.2021006941
Blood advances, Vol. 7 Núm. 1 (january 2023) , p. 145-158  
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