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1.
9 p, 634.4 KB Cortical atrophy and amyloid and tau deposition in Down syndrome : A longitudinal study / Padilla, Concepción (Institut d'Investigació Biomèdica Sant Pau) ; Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ; Walpert, Madeleine J. (University of Cambridge. Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry) ; Hong, Young T. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ; Fryer, Tim D. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ; Coles, Jonathan (University of Cambridge. Division of Anaesthesia. Department of Medicine) ; Aigbirhio, Franklin I. (University of Cambridge. Wolfson Brain Imaging Centre. Department of Clinical Neurosciences) ; Hartley, Sigan L. (University of Wisconsin-Madison. Waisman Center) ; Cohen, Ann (University of Pittsburgh. Department of Psychiatry) ; Tudorascu, Dana L. (University of Pittsburgh. Department of Psychiatry) ; Christian, Bradley T. (University of Wisconsin-Madison. Waisman Center) ; Handen, Benjamin L. (University of Pittsburgh. Department of Psychiatry) ; Klunk, William E. (University of Pittsburgh. Department of Psychiatry) ; Holland, Anthony John (Cambridgeshire and Peterborough NHS Foundation Trust. Fulbourn Hospital) ; Zaman, Shahid H. (Cambridgeshire and Peterborough NHS Foundation Trust. Fulbourn Hospital)
Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at time point 1 (TP1) could predict cortical thickness change at time point 2 (TP2). [...]
2022 - 10.1002/dad2.12288
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 14 Núm. 1 (2022) , p. e12288  
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2.
10 p, 497.8 KB The AT(N) framework for Alzheimer's disease in adults with Down syndrome / Rafii, Michael S. (University of Southern California) ; Ances, Beau M. (Washington University School of Medicine in St. Louis) ; Schupf, Nicole (Columbia University Medical Center) ; Krinsky-McHale, Sharon J. (NYS Institute for Basic Research in Developmental Disabilities) ; Mapstone, Mark (University of California) ; Silverman, Wayne (University of California) ; Lott, Ira (University of California) ; Klunk, Willian (University of Pittsburgh) ; Head, Elizabeth (University of California) ; Christian, Brad (University of Wisconsin Madison) ; Lai, Florence (Massachusetts General Hospital (Boston)) ; Rosas, H.Diana (Harvard Medical School) ; Zaman, Shahid (Cambridgeshire and Peterborough NHS Foundation Trust) ; Petersen, Melissa E. (University of North Texas Health Science Center) ; Strydom, Andre (King's College London) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Handen, Benjamin (University of Pittsburgh) ; O'Bryant, Sid (University of North Texas Health Science Center) ; Universitat Autònoma de Barcelona
The National Institute on Aging in conjunction with the Alzheimer's Association (NIA-AA) recently proposed a biological framework for defining the Alzheimer's disease (AD) continuum. This new framework is based upon the key AD biomarkers (amyloid, tau, neurodegeneration, AT[N]) instead of clinical symptoms and represents the latest understanding that the pathological processes underlying AD begin decades before the manifestation of symptoms. [...]
2020 - 10.1002/dad2.12062
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 12 Núm. 1 (2020) , p. e12062  
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3.
10 p, 344.1 KB Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer's disease / Aschenbrenner, A.J. (Washington University in St. Louis. Department of Neurology) ; Asaad Baksh, R. (The London Down Syndrome (LonDownS) Consortium) ; Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ; Beresford-Webb, J.A. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ; Coppus, Antonia (Department of Primary and Community Care. Radboud University Medical Center) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Handen, Benjamin L (Department of Psychiatry. University of Pittsburgh) ; Hartley, S. (Department of Human Development & Family Studies. University of Wisconsin-Madison) ; Head, E. (Department of Pathology & Laboratory Medicine. University of California) ; Jaeger, J. (Deptment of Psychiatry and Behavioral Sciences. Albert Einstein College of Medicine) ; Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ; Loosli, S.V. (Department of Neurology. Ludwig-Maximilians-UniversitätMünchen) ; Rebillat, A.S. (Jerome Lejeune Institute) ; Sacco, S. (Jerome Lejeune Institute) ; Schmitt, F.A. (Departments of Neurology. Neurosurgery. Behavioral Science. Psychology. Psychiatry. University of Kentucky) ; Thurlow, K.E. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ; Zaman, S. (Cambridgeshire & Peterborough NHS Foundation Trust) ; Hassenstab, J. (Washington University in St. Louis. Department of Neurology) ; Strydom, A. (South London and the Maudsley NHS Foundation Trust)
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. [...]
2021 - 10.1002/dad2.12184
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 13 Núm. 1 (2021) , p. e12184  
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4.
9 p, 938.4 KB Conducting clinical trials in persons with Down syndrome : summary from the NIH INCLUDE Down syndrome clinical trials readiness working group / Baumer, Nicole (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ; Becker, Mara L. (Duke University School of Medicine) ; Capone, George (The Johns Hopkins School of Medicine) ; Egan, Kathleen (Parent/Advocate, Virginia, USA) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Handen, Benjamin L. (University of Pittsburgh) ; Head, Elizabeth (University of California) ; Hendrix, James E. (LuMind IDSC Foundation, Burlington, USA) ; Litovsky, Ruth Y. (University of Wisconsin) ; Strydom, Andre (King's College London) ; Tapia, Ignacio E. (University of Pennsylvania) ; Rafii, Michael S. (University of Southern California) ; Universitat Autònoma de Barcelona
The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). [...]
2022 - 10.1186/s11689-022-09435-z
Journal of Neurodevelopmental Disorders, Vol. 14 (march 2022)  
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5.
16 p, 930.6 KB Assessing general cognitive and adaptive abilities in adults with Down syndrome : a systematic review / Hamburg, Sarah (The London Down Syndrome Consortium (LonDownS), London, UK) ; Lowe, Bryony (Loughborough University. Department of Psychology) ; Startin, Carla Marie (The London Down Syndrome Consortium (LonDownS), London, UK) ; Padilla, Concepción (Department of Psychiatry, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ UK) ; Coppus, Antonia (Radboud University Medical Center. Department of Primary and Community Care) ; Silverman, Wayne (University of California. Department of Pediatrics) ; Fortea, Juan (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Zaman, Shahid (Department of Psychiatry, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ UK) ; Head, Elizabeth (University of Kentucky. Sanders-Brown Center on Aging) ; Handen, Benjamin L. (University of Pittsburgh School of Medicine. Department of Psychiatry) ; Lott, Ira (University of California. Departments of Pediatrics and Neurology) ; Song, Weihong (The University of British Columbia. Townsend Family Laboratories, Department of Psychiatry) ; Strydom, André (The London Down Syndrome Consortium (LonDownS), London, UK)
NOUAB.
Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. [...]
2019 - 10.1186/s11689-019-9279-8
Journal of Neurodevelopmental Disorders, Vol. 11 (august 2019)  
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1 Handen, Benjamin L
3 Handen, Benjamin L.
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