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39.
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8 p, 1.2 MB |
Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity
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Taxerås, Siri D. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Galán, María (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Campderrós, Laura (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Piquer García, Irene (Institut Germans Trias i Pujol) ;
Pellitero, Silvia (Institut Germans Trias i Pujol) ;
Martínez, Eva (Institut Germans Trias i Pujol) ;
Puig, Rocío (Institut Germans Trias i Pujol) ;
Lucena, Icíar (v) ;
Tarascó, Jordi (Institut Germans Trias i Pujol) ;
Moreno, Pau (Institut Germans Trias i Pujol) ;
Balibrea Del Castillo, José María (Hospital Universitari Vall d'Hebron) ;
Bel, Joan (Institut Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol) ;
Martínez, María (Institut Germans Trias i Pujol) ;
Ramon-Krauel, Marta (Hospital Sant Joan de Déu (Manresa)) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol) ;
Villarroya, Francesc (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Lerin, Carles (Hospital Sant Joan de Déu (Manresa)) ;
Sánchez-Infantes, David (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Objectives: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. [...]
2020 -  10.1002/osp4.381
Obesity Science and Practice, Vol. 6 Núm. 1 (january 2020) , p. 99-106
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40.
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167 p, 3.4 MB |
Prevalença de malaltia cardiovascular subclínica i associació amb factors de risc cardiovasculars no clàssics en el pacient amb diabetis mellitus tipus 1
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Serra Planas, Enric ;
Aguilera, Eva, dir. ;
Puig Domingo, Manuel, dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
El maneig i el seguiment dels factors de risc cardiovascular clàssics com la hipertensió arterial, la hipercolesterolèmia, la hiperglucèmia i el tabaquisme no han aconseguit modificar la causa principal de morbimortalitat dels pacients amb diabetis mellitus del tipus 1, la malaltia arterial coronària. [...]
The management and monitoring of classical cardiovascular risk factors such as hypertension, hypercholesterolemia, hyperglycaemia and smoking habit have not been able to modify the main cause of morbidity and mortality in patients with type 1 diabetes mellitus, the coronary artery disease. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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41.
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132 p, 12.9 MB |
Efecto de la inhibición de la molécula CD26/DPPIV sobre los mecanismos de tolerancia inmunológica central y periférica en el ratón diabético no obeso
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Julián Alagarda, María Teresa ;
Puig Domingo, Manuel, dir. ;
Alonso Pedrol, Núria, dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
La molécula CD26, también conocida con dipeptidilpeptidasa IV (DPPIV), es una glicoproteína multifuncional transmembrana tipo II con actividad peptidasa intrínseca en su dominio extracelular. Se ha descrito que la inhibición de la molécula CD26 puede prevenir e incluso revertir la diabetes de reciente diagnóstico en el ratón NOD (non obese diabetic). [...]
The type II transmembrane glycoprotein CD26, also known as dipeptidyl peptidase IV, is a multifunctional protein. domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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42.
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9 p, 1.3 MB |
Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis
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Losada-Grande, Eladio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hawley, Samuel (University of Oxford) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Laguna, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Nogués Solán, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prieto-Alhambra, Daniel (University of Oxford)
Despite normal to high bone mineral density, patients with type 2 diabetes (T2DM) have an increased fracture risk. T2DM medications could partially account for this excess risk. The aim of this study was to assess the association between insulin use and bone fracture risk in T2DM patients. [...]
2017 - 10.1038/s41598-017-03748-z
Scientific reports, Vol. 3 Núm. 378 (june 2017) , p. 1-9
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43.
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8 p, 1.1 MB |
Consistent findings in glycaemic control, body weight and hypoglycaemia with iGlarLixi (insulin glargine/lixisenatide titratable fixed-ratio combination) vs insulin glargine across baseline HbA1c, BMI and diabetes duration categories in the LixiLan-L trial
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Wysham, Carol (Rockwood Clinic (Spokane, Washington)) ;
Bonadonna, Riccardo C (University of Parma) ;
Aroda, Vanita R. (Medstar Health Research Institute (Hyattsville, Maryland)) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Kapitza, Christoph (Profil Institute (Neuss, Alemanya)) ;
Stager, William (Sanofi) ;
Yu, Christine (Sanofi) ;
Niemoeller, Elisabeth (Sanofi) ;
Souhami, Elisabeth (Sanofi) ;
Bergenstal, Richard M. (International Diabetes Center (Minneapolis, Estats Units)) ;
Universitat Autònoma de Barcelona
Aims: To assess the impact of baseline characteristics on clinical outcomes in the LixiLan-L trial, a randomized open-label trial designed to evaluate the efficacy and safety of iGlarLixi, a novel fixed-ratio combination of insulin glargine 100 U (iGlar) plus lixisenatide, in comparison with iGlar over 30 weeks in a population of patients with type 2 diabetes mellitus (T2DM) inadequately controlled on a previous regimen of basal insulin alone or in combination with 1 or 2 oral glucose-lowering drugs. [...]
2017 - 10.1111/dom.12961
Diabetes, Obesity and Metabolism, Vol. 19 (2017) , p. 1408-1415
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44.
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6 p, 561.6 KB |
Evaluation of efficacy, safety, pain perception and health-related quality of life of percutaneous ethanol injection as first-line treatment in symptomatic thyroid cysts
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Reverter, Jordi L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Avila, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lucas Martín, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Centro de Investigación Biomédica en Red Diabetis y Efermedades Metabólicas Asociadas (CIBERDEM) ;
Universitat Autònoma de Barcelona
To evaluate the efficacy, safety, pain perception and health-related quality of life (QoL) of percutaneous ethanol injection treatment (PEIT) as an alternative to thyroid surgery in symptomatic thyroid cysts. [...]
2015 - 10.1186/s12902-015-0069-3
BMC Endocrine Disorders, Vol. 15 (november 2015)
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45.
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46.
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17 p, 249.1 KB |
Ghrelin Gene Variants Influence on Metabolic Syndrome Components in Aged Spanish Population
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Mora, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Adam, Victoria (Hospital Clínic Universitari (València)) ;
Palomera, Elisabet (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Blesa, Sebastián (Hospital Clínic Universitari (València)) ;
Díaz-Soto, Gonzalo (Hospital Clínico Universitario de Valladolid) ;
Buquet, Xavier (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Serra-Prat, Mateu (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Martín-Escudero, Juan Carlos (Hospital Universitario Río Hortega (Valladolid)) ;
Palanca, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Chaves, Javier Felipe (Hospital Clínic Universitari (València)) ;
Puig Domingo, Manuel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Mataró Aging Study Group
BACKGROUND: The role of genetic variations within the ghrelin gene on cardiometabolic profile and nutritional status is still not clear in humans, particularly in elderly people. OBJECTIVES: We investigated six SNPs of the ghrelin gene and their relationship with metabolic syndrome (MS) components. [...]
2015 - 10.1371/journal.pone.0136931
PloS one, Vol. 10 Núm. 9 (september 2015)
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47.
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7 p, 877.3 KB |
Relationship of YKL-40 and adiponectin and subclinical atherosclerosis in asymptomatic patients with type 1 diabetes mellitus from a European Mediterranean population
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Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra Planas, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Granada, Maria Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pellitero Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reverter, Jordi L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations of both markers have been reported in patients with type 1 diabetes (T1D). [...]
2015 - 10.1186/s12933-015-0287-z
Cardiovascular diabetology, Vol. 14, Núm. 121 (September 2015)
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48.
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22 p, 1.1 MB |
Type 1 diabetes prevention in NOD mice by targeting DPPIV/CD26 is associated with changes in CD8+T effector memory subset
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Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrascal, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Miñarro Alonso, Antoni (Universitat de Barcelona. Departament d'Estadística) ;
Ruiz de Villa, María del Carmen (Universitat de Barcelona. Departament d'Estadística) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
CD26 is a T cell activation marker consisting in a type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
2015 - 10.1371/journal.pone.0142186
PloS one, Vol. 10, Issue 11 (Novembre 2015) , p. e0142186
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