Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity
Taxerås, Siri D. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Galán, María (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Campderrós, Laura (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Piquer García, Irene (Institut Germans Trias i Pujol)
Pellitero, Silvia (Institut Germans Trias i Pujol)
Martínez, Eva (Institut Germans Trias i Pujol)
Puig, Rocío (Institut Germans Trias i Pujol)
Lucena, Icíar (v)
Tarascó, Jordi (Institut Germans Trias i Pujol)
Moreno, Pau (Institut Germans Trias i Pujol)
Balibrea Del Castillo, José María (Hospital Universitari Vall d'Hebron)
Bel, Joan (Institut Germans Trias i Pujol)
Murillo-Vallés, Marta (Institut Germans Trias i Pujol)
Martínez, María (Institut Germans Trias i Pujol)
Ramon-Krauel, Marta (Hospital Sant Joan de Déu (Manresa))
Puig Domingo, Manuel (Institut Germans Trias i Pujol)
Villarroya, Francesc (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Lerin, Carles (Hospital Sant Joan de Déu (Manresa))
Sánchez-Infantes, David (Institut Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Objectives: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. To obtain a deeper understanding of the role of S100A4 in obesity, (a) S100A4 levels were measured in prepubertal children and adult subjects with and without obesity and studied the relationship with IR and (b) the effects of S100A4 in cultured human adipocytes and vascular smooth muscle cells (VSMCs) were determined. Methods: Sixty-five children (50 with obesity, age 9. 0 ±1. 1 years and 15 normal weight, age 8. 4 ±0. 8 years) and fifty-nine adults (43 with severe obesity, age 46 ±11 years and 16 normal weight, age 45 ±9 years) were included. Blood from children and adults and adipose tissue samples from adults were obtained and analysed. Human adipocytes and VSMC were incubated with S100A4 to evaluate their response to this adipokine. Results: Circulating S100A4 levels were increased in both children (P =. 002) and adults (P <. 001) with obesity compared with their normal-weight controls. In subjects with obesity, S100A4 levels were associated with homeostatic model assessment-insulin resistance (HOMA-IR) in adults (βstd =. 42, P =. 008) but not in children (βstd =. 12, P =. 356). Human adipocytes were not sensitive to S100A4, while incubation with this adipokine significantly reduced inflammatory markers in VSMC. Conclusions: Our human data demonstrate that higher S100A4 levels are a marker of IR in adults with obesity but not in prepubertal children. Furthermore, the in vitro results suggest that S100A4 might exert an anti-inflammatory effect. Further studies will be necessary to determine whether S100A4 can be a therapeutic target for obesity.
Ajuts:	Instituto de Salud Carlos III PT13-0010-0009
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	S100A4 ; Insulin resistance ; Obesity ; Prepubertal children
Publicat a:	Obesity Science and Practice, Vol. 6 Núm. 1 (january 2020) , p. 99-106, ISSN 2055-2238

DOI: 10.1002/osp4.381
PMID: 32128247

8 p, 1.2 MB

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