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24 p, 507.9 KB |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life
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Santos García, Diego (Complejo Hospitalario Universitario de A Coruña) ;
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol) ;
Cores Bartolomé, Carlos (Complejo Hospitalario Universitario de A Coruña) ;
Feal Painceiras, Maria J. (Complejo Hospitalario Universitario de A Coruña) ;
Íñiguez-Alvarado, Maria Cristina (Complejo Hospitalario Universitario de A Coruña) ;
García Díaz, Iago (Complejo Hospitalario Universitario de A Coruña) ;
Jesús, Silvia (CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Madrid) ;
Buongiorno, Maria Teresa (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Planellas, Lluis (Clínica del Pilar, Barcelona) ;
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona) ;
García Caldentey, Juan (Centro Neurológico Oms 42, Palma de Mallorca) ;
Caballol, Nuria (Complex Hospitalari Moisès Broggi) ;
Legarda, Inés (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Cabo-Lopez, Iria (Complejo Hospitalario Universitario de Pontevedra) ;
López Manzanares, Lydia (Hospital Universitario de la Princesa (Madrid)) ;
Gonzalez-Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Ávila Rivera, Maria A. (Hospital General de LΉospitalet) ;
Gómez Mayordomo, Víctor (Hospital Universitario Clínico San Carlos (Madrid)) ;
Nogueira, Víctor (Hospital Da Costa) ;
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya)) ;
Dotor García-Soto, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Borrué, Carmen (Hospital Universitario Infanta Sofía) ;
Solano Vila, Berta (Institut d'Assistència Sanitària (IAS) - Institut Cataè de la Salut) ;
Álvarez Sauco, María (Hospital General Universitario de Elche) ;
Vela, Lydia (Fundación Hospital de Alcorcón, Madrid) ;
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta) ;
Cubo, Esther (Complejo Asistencial Universitario de Burgos) ;
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna)) ;
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Sánchez Alonso, Pilar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Alonso Losada, Maria G. (Complejo Hospitalario Universitario de Vigo (CHUVI)) ;
López Ariztegui, Nuria (Complejo Hospitalario de Toledo, Toledo) ;
Gastón, Itziar (Complejo Hospitalario de Navarra, Pamplona) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Mendez-Gonzalez, Manuel (Hospital Universitario Central de Asturias) ;
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra) ;
Ruiz Martínez, Javier (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Valero, Caridad (Hospital Arnau de Vilanova (València)) ;
Kurtis, Mónica (Hospital Ruber Internacional) ;
González Ardura, Jessica (Hospital de Cabueñes) ;
Alonso Redondo, Ruben (Hospital Universitario Lucus Augusti (Lugo)) ;
Ordás, Carlos (Hospital Universitario Rey Juan Carlos (Madrid)) ;
López Díaz, Luis M. (Complejo Hospitalario Universitario de Vigo (CHUVI)) ;
McAfee, Darrian (University of Maryland School of Medicine) ;
Calopa, Matilde (Hospital Universitari de Bellvitge) ;
Carrillo, Fátima (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED)) ;
Escamilla Sevilla, Francisco (Hospital Universitario Virgen de las Nieves (Granada)) ;
Freire-Alvarez, Eric (Hospital General Universitario de Elche) ;
Gómez Esteban, Juan Carlos (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
García-Ramos, Rocío (Hospital Clínico San Carlos (Madrid)) ;
Luquin, Maria-Rosario (ínica Universidad de Navarra) ;
Martínez-Torres, Irene (Hospital Universitari i Politècnic La Fe (València)) ;
Sesar Ignacio, Ángel (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Mir, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. [...]
2023 -  10.3233/JPD-225073
Journal of Parkinson's Disease, Vol. 13 (may 2023) , p. 379-402
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11 p, 2.0 MB |
Thimet oligopeptidase as a potential CSF biomarker for Alzheimer's disease : A cross-platform validation study
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Hok-A-Hin, Yanaika S. (VU University Medical Center) ;
Bolsewig, Katharina (VU University Medical Center) ;
Ruiters, Daimy N. (VU University Medical Center) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lemstra, Afina W. (Vrije Universiteit Amsterdam) ;
van der Flier, Wiesje M (VU University Medical Centers) ;
Teunissen, Charlotte E (VU University Medical Center) ;
del Campo, Marta (Fundació Pasqual Maragall) ;
Universitat Autònoma de Barcelona
Our previous antibody-based cerebrospinal fluid (CSF) proteomics study showed that Thimet oligopeptidase (THOP1), an amyloid beta (Aβ) neuropeptidase, was increased in mild cognitive impairment with amyloid pathology (MCI-Aβ+) and Alzheimer's disease (AD) dementia compared with controls and dementia with Lewy bodies (DLB), highlighting the potential of CSF THOP1 as an early specific biomarker for AD. [...]
2023 - 10.1002/dad2.12456
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 15 (july 2023)
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8 p, 208.5 KB |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease
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Villarejo-Galende, Alberto (Instituto de Salud Carlos III) ;
García-Arcelay, E. (Roche Farma) ;
Piñol-Ripoll, G. (Hospital de Santa Maria (Lleida, Catalunya)) ;
Del Olmo-Rodríguez, A. (Hospital Universitari Doctor Peset (València)) ;
Viñuela, F. (Hospital Universitario Virgen Macarena) ;
Boada, M. (Universitat Internacional de Catalunya) ;
Franco-Macías, E. (Instituto de Biomedicina de Sevilla) ;
Ibañez De La Peña, A. (Policlínica Guipúzcoa) ;
Riverol, M. (Universidad de Navarra) ;
Puig-Pijoan, Albert (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Abizanda-Soler, Pedro (Complejo Hospitalario Universitario de Albacete) ;
Arroyo, Rafael (Hospital Universitario Quirónsalud) ;
Baquero-Toledo, M. (Hospital Universitari i Politècnic la Fe) ;
Feria-Vilar, Inmaculada (Complejo Hospitalario Universitario de Albacete) ;
Balasa, M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Berbel, Á. (Hospital Central de la Cruz Roja) ;
Rodríguez-Rodríguez, E. (Universidad de Cantabria) ;
Vieira-Campos, A. (Hospital Universitario de la Princesa) ;
García-Ribas, G. (Instituto de Investigación Hospital 12 de Octubre) ;
Rodrigo-Herrero, S. (Instituto de Investigación Hospital 12 de Octubre) ;
Terrancle, Á. (Roche Farma) ;
Prefasi, D. (Roche Farma) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Maurino, J. (Roche Farma) ;
Universitat Autònoma de Barcelona
Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. [...]
2022 - 10.3233/JAD-220696
Journal of Alzheimer's disease, Vol. 90 Núm. 2 (2022) , p. 719-726
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9 p, 1.1 MB |
Impact of Diabetes on 10-Year Outcomes Following ST-Segment-Elevation Myocardial Infarction : Insights From the EXAMINATION-EXTEND Trial
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Spione, Francesco (Hospital Clínic i Provincial de Barcelona) ;
Arevalos, Victor (Hospital Clínic i Provincial de Barcelona) ;
Gabani, Rami (Hospital Clínic i Provincial de Barcelona) ;
Ortega-Paz, Luis (University of Florida College of Medicine) ;
Gomez Lara, Josep (Hospital Universitari de Bellvitge) ;
Jimenez-Diaz, Victor (Instituto De Investigación Sanitaria Galicia Sur) ;
Jimenez, Marcelo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Jiménez-Quevedo, Pilar (Hospital Clínico San Carlos (Madrid)) ;
Diletti, Roberto (Thoraxcenter (Rotterdam, Països Baixos)) ;
Pineda Rocamora, Javier (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Campo, Gianluca (Azienda Ospedaliera Universitaria di Ferrara (Cona, Itàlia)) ;
Silvestro, Antonio (University Hospital Bolognini Seriate (Bergamo, Itàlia)) ;
Maristany, Jaume (Hospital Universitari Son Dureta (Palma de Mallorca, Balears)) ;
Flores, Xacobe (Hospital Universitario A Coruña (Galícia)) ;
Oyarzabal, Loreto (Hospital Universitari de Bellvitge) ;
Bastos Fernández, Guillermo (Instituto De Investigación Sanitaria Galicia Sur) ;
Iñiguez, Andrés (Hospital Álvaro Cunqueiro (Vigo)) ;
Serra, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Escaned, Javier (Hospital Clínico San Carlos (Madrid)) ;
Ielasi, Alfonso (University Hospital Bolognini Seriate (Bergamo, Itàlia)) ;
Tespili, Maurizio (University Hospital Bolognini Seriate (Bergamo, Itàlia)) ;
Lenzen, Mattie (Thoraxcenter (Rotterdam, Països Baixos)) ;
Gonzalo, Nieves (Hospital Universitario Clínico San Carlos (Madrid)) ;
Bordes, Pascual (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Tebaldi, Matteo (Azienda Ospedaliera Universitaria di Ferrara (Cona, Itàlia)) ;
Biscaglia, Simone (Azienda Ospedaliera Universitaria di Ferrara (Cona, Itàlia)) ;
Al-Shaibani, Soheil (Thoraxcenter (Rotterdam, Països Baixos)) ;
Romaguera, Rafael (Hospital Universitari de Bellvitge) ;
Gomez-Hospital, Joan Antoni (Hospital Universitari de Bellvitge) ;
Rodes-Cabau, Josep (Hospital Clínic i Provincial de Barcelona) ;
Serruys, Patrick W. (National University of Ireland (Galway, Irlanda)) ;
Sabaté Tenas, Manel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Brugaletta, Salvatore (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Long-term outcomes of ST-segment-elevation myocardial infarction in patients with diabetes have been barely investigated. The objective of this analysis from the EXAMINATION-EXTEND (10-Years Follow-Up of the EXAMINATION trial) trial was to compare 10-year outcomes of patients with ST-segment-elevation myocardial infarction with and without diabetes. [...]
2022 - 10.1161/JAHA.122.025885
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 11 Núm. 23 (2022) , p. e025885
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11 p, 1.2 MB |
Repair of Aortic Regurgitation in Young Adults : Sooner Rather Than Later
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Barradas-Pires, Ana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Merás, Pablo (Hospital Universitario La Paz (Madrid)) ;
Constantine, Andrew (Imperial College London) ;
Costola, Giulia (Guy's and St Thomas' NHS Foundation Trust) ;
de la Cal, Teresa Segura (Hospital 12 de Octubre (Madrid)) ;
Rafiq, Isma (Guy's and St Thomas' NHS Foundation Trust) ;
Kempny, Aleksander (Imperial College London) ;
Li, Wei (Imperial College London) ;
Babu-Narayan, Sonya V. (Imperial College London) ;
Hoschtitzky, J. Andreas (Guy's and St Thomas' NHS Foundation Trust) ;
Gatzoulis, Michael A. (Imperial College London) ;
Rubio, Antonio Martinez (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Dimopoulos, Konstantinos (Imperial College London)
Establishing surgical criteria for aortic valve replacement (AVR) in severe aortic regurgitation in young adults is challenging due to the lack of evidence-based recommendations. We studied indications for AVR in young adults with severe aortic regurgitation and their outcomes, as well as the relationship between presurgical echocardiographic parameters and postoperative left ventricular (LV) size, function, clinical events, and valve-related complications. [...]
2023 - 10.1161/JAHA.122.029251
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 12 (september 2023)
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52 p, 705.6 KB |
Role of Amyloid-β and Tau Proteins in Alzheimer's Disease : Confuting the Amyloid Cascade
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Gulisano, W. (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Maugeri, Daniele (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fà, Mauro (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University) ;
Amato, Arianna (Department of Anaesthesiology. Università Cattolica Del Sacro Cuore) ;
Palmeri, Agostino (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
D'Adamio, Luciano (Department of Pharmacology. Physiology and Neuroscience. Rutgers University) ;
Grassi, Claudio (Institute of Human Physiology. Università Cattolica Del Sacro Cuore) ;
Devanand, D.P. (Department of Psychiatry. Columbia University. College of Phys. and Surg.) ;
Honig, Lawrence S. (Department of Neurology. Columbia University. College of Phys. and Surg.) ;
Puzzo, Daniela (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ;
Arancio, Ottavio (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University)
The "Amyloid Cascade Hypothesis" has dominated the Alzheimer's disease (AD) field in the last 25 years. It posits that the increase of amyloid-β (Aβ) is the key event in AD that triggers tau pathology followed by neuronal death and eventually, the disease. [...]
2018 - 10.3233/JAD-179935
Journal of Alzheimer's disease, Vol. 64 Núm. s1 (2018) , p. S611-S631
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6 p, 2.0 MB |
The colon does not reach! A technical note with tricks to avoid colorectal anastomoses under tension
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Dalmau, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marti-Gallostra, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pellino, Gianluca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espin-Basany, Eloy (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Armengol Carrasco, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Departament de Cirurgia
Aim: We describe two options for colorectal anastomosis suitable in cases when the colon would reach the pelvis under tension. Method: Deloyers procedure and the retro-ileal colorectal anastomosis are presented, focusing on practical tips and tricks to perform them. [...]
2024 - 10.1111/codi.16865
Colorectal Disease, Vol. 26, Num. 3 (march 2024) , p. 564-569
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9 p, 1.0 MB |
Rotigotine transdermal patch and sleep in Parkinson's disease : where are we now?
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Rosa-Grilo, Miguel (King's College London) ;
Qamar, Mubasher A. (King's College London) ;
Taddei, Raquel N. (King's College London) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Sauerbier, Anna (King's College London) ;
Chaudhuri, K.Ray (King's College London) ;
Universitat Autònoma de Barcelona
A wide range of sleep dysfunction complicates Parkinson's disease during its course from prodromal to palliative stage. It is now increasingly acknowledged that sleep disturbances are thus integral to the disease and pose a significant burden impacting on quality of life of patients. [...]
2017 - 10.1038/S41531-017-0030-4
NPJ Parkinson's disease, Vol. 3 Núm. 1 (2017) , p. 28
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7 p, 841.1 KB |
High-Sensitivity Troponin T and Soluble Form of AXL as Long-Term Prognostic Biomarkers after Heart Transplantation
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Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ;
García-Osuna, Alvaro (Institut d'Investigació Biomèdica Sant Pau) ;
García de Frutos, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ferrero-Gregori, Andreu (Institut d'Investigació Biomèdica Sant Pau) ;
Brossa Loidi, Vicens (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lopez, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Leta, Ruben (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Garcia-Picart, Joan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Padro, Josep M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sánchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Ordonez-Llanos, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Roig, Eulalia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Cardiac allograft vasculopathy (CAV) is a frequent complication limiting the long-term (>1 year) survival after heart transplantation (HTx). CAV is initiated by endothelial dysfunction and can lead to severe cardiovascular (CV) complications. [...]
2018 - 10.1155/2018/6243529
Disease markers, Vol. 2018 (2018) , p. 6243529
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