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18 p, 1.8 MB

Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection / Gallardo-Gómez, María (Universidade de Vigo) ; Costas-Ríos, Lara (Universidade de Vigo) ; García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Álvarez-Rodríguez, Lara (Universidade de Vigo) ; Bujanda, Luis (Universidad del País Vasco) ; Barrero, Maialen (Hospital de Donostia (Sant Sebastià, País Basc)) ; Castells, Antoni (Hospital Clínic i Provincial de Barcelona) ; Balaguer, Francesc (Hospital Clínic i Provincial de Barcelona) ; Jover, Rodrigo (Universidad Miguel Hernández, Alicante) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Tardío Baiges, Antoni (Instituto de Investigación Biomédica Galicia Sur) ; González-Carreró Fojón, Joaquín (Instituto de Investigación Biomédica Galicia Sur) ; Cubiella, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Ourense) ; De Chiara, Loretta (Universidade de Vigo)
The clinical relevance of the colorectal cancer serrated pathway is evident, but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway and to evaluate circulating cell-free DNA (cfDNA) methylomes as a potential source of biomarkers for the non-invasive detection of serrated lesions. [...]
2023 - DOI (Digital Object Identifier)