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9 p, 2.7 MB |
Genetic association study of childhood aggression across raters, instruments, and age
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Ip, Hill F. (Vrije Universiteit Amsterdam) ;
van der Laan, Camiel M. (Netherlands Institute for the Study of Crime and Law Enforcement) ;
Krapohl, Eva M. L. (King's College London) ;
Brikell, Isabell (Karolinska Institutet (Estocolm, Suècia)) ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nolte, Ilja M. (University of Groningen) ;
Pourcain, Beate St (Radboud University) ;
Bolhuis, Koen (Erasmus University Medical Center) ;
Palviainen, Teemu (University of Helsinki) ;
Zafarmand, Hadi (University of Amsterdam) ;
Colodro-Conde, Lucía (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Gordon, Scott D (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Zayats, Tetyana (Stanley Center for Psychiatric Research) ;
Aliev, Fazil (Karabuk University) ;
Jiang, Chang (University of Florida) ;
Wang, Carol A. (The University of Newcastle) ;
Saunders, Gretchen (University of Minnesota) ;
Karhunen, Ville (Imperial College London) ;
Hammerschlag, Anke R. (Amsterdam Public Health Research Institute) ;
Adkins, Daniel E. (University of Utah) ;
Border, Richard (University of Colorado Boulder) ;
Peterson, Roseann E. (Virginia Commonwealth University) ;
Prinz, Joseph A. (Duke University) ;
Thiering, Elisabeth (Ludwig-Maximilians-University of Munich) ;
Seppälä, Ilkka (Tampere University) ;
Vilor-Tejedor, Natàlia (Fundació Pasqual Maragall (FPM)) ;
Ahluwalia, Tarunveer Singh (Steno Diabetes Center Copenhagen) ;
Day, Felix R. (University of Cambridge School of Clinical Medicine) ;
Hottenga, Jouke Jan (Vrije Universiteit Amsterdam) ;
Allegrini, Andrea G. (King's College London) ;
Rimfeld, Kaili (King's College London) ;
Chen, Qi (Karolinska Institutet (Estocolm, Suècia)) ;
Lu, Yi (Karolinska Institutet (Estocolm, Suècia)) ;
Martin, Joanna (Cardiff University) ;
Soler Artigas, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bosch, Rosa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Español-Martín, Gemma (Hospital Universitari Vall d'Hebron) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Neumann, Alexander (Jewish General Hospital) ;
Ensink, Judith (De Bascule, Academic Centre for Child and Adolescent Psychiatry) ;
Grasby, Katrina (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Morosoli, José J. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Tong, Xiaoran (University of Florida) ;
Marrington, Shelby (The University of Queensland) ;
Middeldorp, Christel (Children's Health Queensland Hospital) ;
Scott, James G. (Queensland Centre for Mental Health Research) ;
Vinkhuyzen, Anna (University of Queensland) ;
Shabalin, Andrey A. (University of Utah) ;
Corley, Robin (University of Colorado Boulder) ;
Evans, Luke M. (University of Colorado Boulder) ;
Sugden, Karen (Duke University) ;
Alemany, Sílvia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Sass, Lærke (University of Copenhagen) ;
Vinding, Rebecca (University of Copenhagen) ;
Ruth, Kate (University of Exeter Medical School) ;
Tyrrell, Jess (University of Exeter Medical School) ;
Davies, Gareth E. (Avera Institute for Human Genetics) ;
Ehli, Erik A. (Avera Institute for Human Genetics) ;
Hagenbeek, Fiona A. (Vrije Universiteit Amsterdam) ;
De Zeeuw, Eveline (Vrije Universiteit Amsterdam) ;
Van Beijsterveldt, Toos C.E.M. (Vrije Universiteit Amsterdam) ;
Larsson, Henrik (Orebro University) ;
Snieder, Harold (University of Groningen) ;
Verhulst, Frank C. (Copenhagen University Hospital) ;
Amin, Najaf (Erasmus University Medical Center) ;
Whipp, Alyce M. (University of Helsinki) ;
Korhonen, Tellervo (University of Helsinki) ;
Vuoksimaa, Eero (University of Helsinki) ;
Rose, Richard J. (Indiana University) ;
Uitterlinden, André G. (Netherlands Genomics Initiative (NGI)) ;
Heath, Andrew C. (Washington University) ;
Madden, Pamela (Washington University) ;
Haavik, Jan (Haukeland University Hospital (Bergen, Noruega)) ;
Harris, Jennifer R. (The Norwegian Institute of Public Health) ;
Helgeland, Øyvind (The Norwegian Institute of Public Health) ;
Johansson, Stefan E (University of Bergen) ;
Knudsen, Gun Peggy S. (The Norwegian Institute of Public Health) ;
Njolstad, Pal Rasmus (University of Bergen) ;
Lu, Qing (University of Florida) ;
Rodriguez, Alina (University of Lincoln) ;
Henders, Anjali K. (University of Queensland) ;
Mamun, Abdullah (University of Queensland) ;
Najman, Jackob M. (The University of Queensland) ;
Brown, Sandy (University of California) ;
Hopfer, Christian (University of Colorado School of Medicine) ;
Krauter, Kenneth (University of Colorado Boulder) ;
Reynolds, Chandra (University of California Riverside) ;
Smolen, Andrew (University of Colorado Boulder) ;
Stallings, Michael (University of Colorado Boulder) ;
Wadsworth, Sally (University of Colorado Boulder) ;
Wall, Tamara L. (University of California) ;
Silberg, Judy L. (Virginia Commonwealth University) ;
Miller, Allison (University of Otago Christchurch) ;
Keltikangas-Järvinen, Liisa (University of Helsinki) ;
Hakulinen, Christian (University of Helsinki) ;
Pulkki-Råback, Laura (University of Helsinki) ;
Havdahl, Alexandra (Norwegian Institute of Public Health) ;
Magnus, Per (Norwegian Institute of Public Health) ;
Raitakari, Olli T. (Turku University Hospital) ;
Perry, John R. B. (University of Cambridge School of Clinical Medicine) ;
Llop, Sabrina (Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Lopez-Espinosa, Maria-Jose (Universitat de València) ;
Bønnelykke, Klaus (University of Copenhagen) ;
Bisgaard, Hans (University of Copenhagen) ;
Sunyer Deu, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lehtimäki, Terho (Tampere University) ;
Arseneault, Louise (Duke University School of Medicine) ;
Standl, Marie (Helmholtz Zentrum München) ;
Heinrich, Joachim (University of Melbourne) ;
Boden, Joseph (University of Otago Christchurch) ;
Pearson, John (University of Otago Christchurch) ;
Horwood, L. John (University of Otago Christchurch) ;
Kennedy, Martin (University of Otago Christchurch) ;
Poulton, Richie (University of Otago) ;
Eaves, Lindon J. (Virginia Institute for Psychiatric and Behavioral Genetics) ;
Maes, Hermine H. (Virginia Commonwealth University) ;
Hewitt, John (University of Colorado Boulder) ;
Copeland, William E. (University of Vermont) ;
Costello, Elizabeth J. (Duke University) ;
Williams, Gail M. (The University of Queensland) ;
Wray, Naomi R (University of Queensland) ;
Järvelin, Marjo-Riitta (University of Oulu) ;
McGue, Matt (University of Minnesota) ;
Iacono, William (University of Minnesota) ;
Caspi, Avshalom (King's College London) ;
Moffitt, Terrie E. (King's College London) ;
Whitehouse, Andrew (The University of Western Australia) ;
Pennell, Craig E. (The University of Newcastle) ;
Klump, Kelly L. (Michigan State University) ;
Burt, S. Alexandra (Michigan State University) ;
Dick, Danielle M. (Virginia Commonwealth University) ;
Reichborn-Kjennerud, Ted (University of Oslo) ;
Martin, Nicholas G (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Medland, Sarah Elizabeth (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Vrijkotte, Tanja (University of Amsterdam) ;
Kaprio, Jaakko (University of Helsinki) ;
Tiemeier, Henning (Harvard TH Chan School of Public Health) ;
Smith, George Davey (University of Bristol) ;
Hartman, Catharina A. (University of Groningen) ;
Oldehinkel, Albertine J (University of Groningen) ;
Casas Brugué, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lichtenstein, Paul (Karolinska Institutet (Estocolm, Suècia)) ;
Lundström, Sebastian (University of Gothenburg) ;
Plomin, Robert (King's College London) ;
Bartels, Meike (Amsterdam Public Health Research Institute) ;
Nivard, Michel G. (Vrije Universiteit Amsterdam) ;
Boomsma, Dorret I (Amsterdam Public Health Research Institute)
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. [...]
2021 -  10.1038/s41398-021-01480-x
Translational psychiatry, Vol. 11 (july 2021)
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10 p, 1.4 MB |
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
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Manry, Jérémy ;
Bastard, Paul ;
Gervais, Adrian ;
Le Voyer, Tom ;
Rosain, Jérémie ;
Philippot, Quentin ;
Michailidis, Eleftherios ;
Hoffmann, Hans-Heinrich ;
Eto, Shohei ;
Garcia-Prat, Marina (Hospital Universitari Vall d'Hebron) ;
Bizien, Lucy ;
Parra-Martínez, Alba (Hospital Universitari Vall d'Hebron) ;
Yang, Rui ;
Haljasmägi, Liis ;
Migaud, Mélanie ;
Särekannu, Karita ;
Maslovskaja, Julia ;
de Prost, Nicolas ;
Tandjaoui-Lambiotte, Yacine ;
Luyt, Charles-Edouard ;
Amador-Borrero, Blanca ;
Gaudet, Alexandre ;
Poissy, Julien ;
Morel, Pascal ;
Richard, Pascale ;
Cognasse, Fabrice ;
Troya, Jesús ;
Trouillet-Assant, Sophie ;
Belot, Alexandre ;
Saker, Kahina ;
Garçon, Pierre ;
Rivière, Jacques G.. (Hospital Universitari Vall d'Hebron) ;
Lagier, Jean-Christophe ;
Gentile, Stéphanie ;
Rosen, Lindsey B. ;
Shaw, Elana ;
Morio, Tomohiro ;
Tanaka, Junko ;
Dalmau, David ;
Tharaux, Pierre-Louis ;
Sene, Damien ;
Stepanian, Alain ;
Mégarbane, Bruno ;
Triantafyllia, Vasiliki ;
Fekkar, Arnaud ;
Heath, James R. ;
Franco, Jose Luis ;
Anaya, Juan-Manuel ;
Solé-Violán, Jordi ;
Imberti, Luisa ;
Biondi, Andrea ;
Bonfanti, Paolo ;
Castagnoli, Riccardo ;
Delmonte, Ottavia M. ;
Zhang, Yu ;
Snow, Andrew ;
Holland, Steven M. ;
Biggs, Catherine M. ;
Moncada-Vélez, Marcela ;
Arias, Andrés Augusto ;
Lorenzo, Lazaro ;
Boucherit, Soraya ;
Anglicheau, Dany ;
Planas, Anna Maria ;
Haerynck, Filomeen ;
Duvlis, Sotirija ;
Ozcelik, Tayfun ;
Keles, Sevgi ;
Bousfiha, Ahmed A. ;
El Bakkouri, Jalila ;
Ramirez-Santana, Carolina ;
Paul, Stephane ;
Pan-Hammarström, Qiang ;
Hammarström, Lennart ;
Dupont, Annabelle ;
Kurolap, Alina ;
Metz, Christine N. ;
Aiuti, Alessandro ;
Casari, Giorgio ;
Lampasona, Vito ;
Ciceri, Fabio ;
Barreiros, Lucila A. ;
Domínguez-Garrido, Elena ;
Vidigal, Mateus ;
Zatz, Mayana ;
van de Beek, Diederik ;
Sahanic, Sabina ;
Tancevski, Ivan ;
Stepanovskyy, Yurii ;
Boyarchuk, Oksana ;
Nukui, Yoko ;
Tsumura, Miyuki ;
Vidaur, Loreto ;
Tangye, Stuart G. ;
Burrel, Sonia ;
Duffy, Darragh ;
Quintana-Murci, Lluis ;
Klocperk, Adam ;
Kann, Nelli Y. ;
Shcherbina, Anna ;
Lau, Yu-Lung ;
Leung, Daniel ;
Coulongeat, Matthieu ;
Marlet, Julien ;
Koning, Rutger ;
Reyes, Luis Felipe ;
Chauvineau-Grenier, Angélique ;
Venet, Fabienne ;
Monneret, Guillaume ;
Nussenzweig, Michel C. ;
Arrestier, Romain ;
Boudhabhay, Idris ;
Baris-Feldman, Hagit ;
Hagin, David ;
Wauters, Joost ;
Meyts, Isabelle ;
Dyer, Adam H. ;
Kennelly, Sean P. ;
Bourke, Nollaig M. ;
Halwani, Rabih ;
Sharif-Askari, Fatemeh Saheb ;
Dorgham, Karim ;
Sallette, Jérôme ;
Sedkaoui, Souad Mehlal ;
AlKhater, Suzan ;
Rigo Bonnin, Raül (Institut d'Investigació Biomèdica de Bellvitge) ;
Morandeira, Francisco ;
Roussel, Lucie ;
Vinh, Donald C. ;
Erikstrup, Christian ;
Condino-Neto, Antonio ;
Prando, Carolina ;
Bondarenko, Anastasiia ;
Spaan, András N. ;
Gilardin, Laurent ;
Fellay, Jacques ;
Lyonnet, Stanislas ;
Bilguvar, Kaya ;
Lifton, Richard P. ;
Mane, Shrikant ;
Anderson, Mark S. ;
Boisson, Bertrand ;
Béziat, Vivien ;
Zhang, Shen-Ying ;
Andreakos, Evangelos ;
Hermine, Olivier ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Peterson, Pärt ;
Mogensen, Trine H. ;
Rowen, Lee ;
Mond, James ;
Debette, Stéphanie ;
De Lamballerie, Xavier ;
Burdet, Charles ;
Bouadma, Lila ;
Zins, Marie ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ;
Gorochov, Guy ;
Solanich, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Susen, Sophie ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Raoult, Didier ;
Vasse, Marc ;
Gregersen, Peter K. ;
Piemonti, Lorenzo ;
Rodríguez-Gallego, Carlos ;
Notarangelo, Luigi ;
Su, Helen C. ;
Kisand, Kai ;
Okada, Satoshi ;
Puel, Anne ;
Jouanguy, Emmanuelle ;
Rice, Charles M. ;
Tiberghien, Pierre ;
Zhang, Qian ;
Casanova, Jean-Laurent ;
Abel, Laurent ;
Cobat, Aurélie ;
Universitat Autònoma de Barcelona
There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. [...]
2022 - 10.1073/pnas.2200413119
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119 (may 2022)
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9 p, 872.2 KB |
The EHA research roadmap : normal hematopoiesis
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Jaffredo, Thierry (Sorbonne Université. Institut de Biologie Paris Seine. Laboratoire de Biologie du Développement/UMR7622) ;
Balduini, Alessandra (Department of Molecular Medicine. University of Pavia) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bernardi, Rosa (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Bonnet, Dominique (The Francis Crick Institute) ;
Canque, Bruno (INSERM U976. Universite de Paris. Ecole Pratique des Hautes Etudes/PSL Research University. Institut de Recherche Saint Louis) ;
Charbord, Pierre (Sorbonne Université. Institut de Biologie Paris Seine. Laboratoire de Biologie du Développement/UMR7622) ;
Cumano, Anna (Unité Lymphopoïèse. Département d'Immunologie. INSERM U1223. Institut Pasteur. Cellule Pasteur. Université de Paris) ;
Delwel, Ruud (Department of Hematology. Erasmus University Medical Center) ;
Durand, Charles (Sorbonne Université. Institut de Biologie Paris Seine. Laboratoire de Biologie du Développement/UMR7622) ;
Fibbe, Willem (Leiden University Medical Center) ;
Forrester, Lesley (Centre for Regenerative Medicine. Institute for Regeneration and Repair. University of Edinburgh) ;
De Franceschi, Lucia (Università degli Studi di Verona) ;
Ghevaert, Cedric (University of Cambridge) ;
Gjertsen, Bjørn. (Department of Clinical Science. Centre for Cancer Biomarkers CCBIO. University of Bergen) ;
Gottgens, Berthold (Wellcome - MRC Cambridge Stem Cell Institute and Department of Haematology. University of Cambridge) ;
Graf, Thomas (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Heidenreich, Olaf (Prinses Máxima Centrum voor kinderoncologie) ;
Hermine, Olivier (Department of Hematology and Laboratory of Physiopathology and Treatment of Blood Disorders. Hôpital Necker. Imagine institute. University of Paris) ;
Higgs, Douglas (MRC Weatherall Institute of Molecular Medicine. John Radcliffe Hospital) ;
Kleanthous, Marina (The Cyprus Institute of Neurology and Genetics) ;
Klump, Hannes (Institute for Transfusion Medicine. University Hospital Essen) ;
Kouskoff, Valerie (University of Manchester) ;
Krause, Daniela (Goethe University Frankfurt and Georg-Speyer-Haus) ;
Lacaud, George (Cancer Research UK Manchester Institute. The University of Manchester) ;
Lo Celso, Cristina (Imperial College London) ;
Martens, Joost H.A. (Department of Molecular Biology. RIMLS. Radboud University) ;
Méndez-Ferrer, Simón (University of Cambridge and NHSBT) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Oostendorp, Robert (Department of Internal Medicine III. Technical University of Munich. School of Medicine) ;
Philipsen, Sjaak (Department of Cell Biology. Erasmus University Medical Center Rotterdam) ;
Porse, Bo (Novo Nordisk Foundation Center for Stem Cell Biology. DanStem. Faculty of Health Sciences. University of Copenhagen) ;
Raaijmakers, Marc (Department of Hematology. Erasmus University Medical Center) ;
Robin, Catherine (Regenerative medicine center. University Medical Center Utrecht) ;
Stunnenberg, Henk (Prinses Máxima Centrum voor kinderoncologie) ;
Theilgaard-Mönch, Kim (Department of Hematology. Rigshospitalet/National University Hospital. University of Copenhagen) ;
Touw, Ivo (Department of Hematology. Erasmus University Medical Center) ;
Vainchenker, William (Gustave Roussy) ;
Corrons, Joan-Lluis V. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Yvernogeau, Laurent (Sorbonne Université. Institut de Biologie Paris Seine. Laboratoire de Biologie du Développement/UMR7622) ;
Schuringa, Jan Jacob (Department of Experimental Hematology. University Medical Center Groningen)
2021 - 10.1097/HS9.0000000000000669
HemaSphere, Vol. 5 Núm. 12 (30 2021) , p. e669
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12 p, 1.1 MB |
Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis : a randomized clinical trial
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Mora, J. S. (ALS Unit. Hospital San Rafael) ;
Genge, A. (Department of Neurology and Neurosurgery. Montreal Neurological Institute and Hospital. McGill University) ;
Chiò, Adriano (Department of Neuroscience. University of Turin) ;
Estol, C. J. (Neurological Center for Treatment and Rehabilitation) ;
Chaverri, D. (Hospital Carlos III (Madrid)) ;
Hernández, M. (Hospital Carlos III (Madrid)) ;
Marín, S. (Hospital Carlos III (Madrid)) ;
Mascias, J. (Hospital Carlos III (Madrid)) ;
Rodriguez, G. E. (Neurology Department. Neuron Motor Disease Clinic. Hospital JM Ramos) ;
Povedano, M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Paipa, A. (Institut d'Investigació Biomèdica de Bellvitge) ;
Dominguez, Raúl (Institut d'Investigació Biomèdica de Bellvitge) ;
Gamez, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salvado, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lunetta, C. (NEMO Clinical Centre. Serena Onlus Foundation) ;
Ballario, C. (Neurorosario) ;
Riva, N. (Department of Neurology-INSPE. San Raffaele Scientific Institute) ;
Mandrioli, J. (Department of Neurosciences. St. Agostino-Estense Hospital. Azienda Ospedaliero Universitaria di Modena) ;
Moussy, A. (AB Science) ;
Kinet, J. P. (Department of Pathology. Harvard Medical School and Beth Israel Deaconess Medical Center) ;
Auclair, C. (Department of Biology. Université Paris Sud Université Paris-Saclay CNRS UMR 8113. Ecole Normale Supérieure de Cachan) ;
Dubreuil, P. (Institut Paoli-Calmettes Cancer Centre (Marsella, França)) ;
Arnold, V. (AB Science) ;
Mansfield, C. D. (AB Science) ;
Hermine, O. (Imagine Institute. INSERM UMR 1163 and CNRS ERL 8254. Laboratory of Cellular and Molecular Mechanisms of Hemathological Disorders and Therapeutic Implication. Hôpital Necker) ;
Universitat Autònoma de Barcelona
Objective: To assess masitinib in the treatment of ALS. Methods: Double-blind study, randomly assigning 394 patients (1:1:1) to receive riluzole (100 mg/d) plus placebo or masitinib at 4. 5 or 3. 0 mg/kg/d. [...]
2020 - 10.1080/21678421.2019.1632346
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 21 Núm. 1-2 (february 2020) , p. 5-14
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