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Artículos, Encontrados 5 registros
Artículos Encontrados 5 registros  
1.
29 p, 401.7 KB Epigenetic targets in B- and T-cell lymphomas : latest developments / Ribeiro, Marcelo L. (Sao Francisco University Medical School) ; Sánchez Vinces, Salvador (Sao Francisco University Medical School) ; Mondragón, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Non-Hodgkin's lymphomas (NHLs) comprise a diverse group of diseases, either of mature B-cell or of T-cell derivation, characterized by heterogeneous molecular features and clinical manifestations. While most of the patients are responsive to standard chemotherapy, immunotherapy, radiation and/or stem cell transplantation, relapsed and/or refractory cases still have a dismal outcome. [...]
2023 - 10.1177/20406207231173485
Therapeutic Advances in Hematology, Vol. 14 (1-12 2023)  
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2.
13 p, 1.6 MB MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma / Vella, Serena (Ospedale Pediatrico Bambino Gesù) ; Pomella, Silvia (Istituto Dermopatico dell'Immacolata) ; Leoncini, Pier Paolo (Ospedale Pediatrico Bambino Gesù) ; Colletti, Marta (Ospedale Pediatrico Bambino Gesù) ; Conti, Beatrice (Ospedale Pediatrico Bambino Gesù) ; Marquez, Victor E. (Frederick National Laboratory for Cancer Research) ; Strillacci, Antonio (University of Bologna) ; Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gallego, Soledad (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Milano, Giuseppe M. (Ospedale Pediatrico Bambino Gesù) ; Capogrossi, Maurizio C. (Istituto Dermopatico dell'Immacolata) ; Bertaina, Alice (Ospedale Pediatrico Bambino Gesù) ; Ciarapica, Roberta (Istituto Dermopatico dell'Immacolata) ; Rota, Rossella (Laboratory of Angiogenesis, Ospedale Pediatrico Bambino Gesù) ; Universitat Autònoma de Barcelona
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 histone H3 methyltransferase that regulates the balance between cell proliferation and differentiation by epigenetically silencing muscle-specific genes. [...]
2015 - 10.1186/s13148-015-0107-z
Clinical Epigenetics, Vol. 7 (august 2015)  
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3.
12 p, 2.2 MB Circulating EZH2-positive T cells are decreased in multiple sclerosis patients / Malhotra, Sunny (Hospital Universitari Vall d'Hebron) ; Villar, Luisa M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Costa, Carme (Hospital Universitari Vall d'Hebron) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ; Cubedo, Marta (Universitat de Barcelona. Departament d'Estadística) ; Medina, Silvia (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Fissolo, Nicolás (Hospital Universitari Vall d'Hebron) ; Río, Jordi (Hospital Universitari Vall d'Hebron) ; Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ; Alvarez-Cermeño, José C (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Sánchez, Alex (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Recent studies in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), suggest an involvement of the histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) in important processes such as cell adhesion and migration. [...]
2018 - 10.1186/s12974-018-1336-9
Journal of neuroinflammation, Vol. 15 (october 2018)  
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4.
31 p, 1.4 MB Histone Modifications and Their Targeting in Lymphoid Malignancies / Fernández-Serrano, Miranda (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Winkler, René (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Roué, Gaël (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
In a wide range of lymphoid neoplasms, the process of malignant transformation is associated with somatic mutations in B cells that affect the epigenetic machinery. Consequential alterations in histone modifications contribute to disease-specific changes in the transcriptional program. [...]
2021 - 10.3390/ijms23010253
International journal of molecular sciences, Vol. 23 (december 2021)  
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5.
24 p, 2.0 MB Recent advances in the targeting of epigenetic regulators in b-cell non-hodgkin lymphoma / Ribeiro, Marcelo L. (Vall d'Hebron Institut d'Oncologia) ; Reyes Garau, Diana (Vall d'Hebron Institut d'Oncologia) ; Armengol, Marc Antoni (Vall d'Hebron Institut d'Oncologia) ; Roué, Gaël (Vall d'Hebron Institut d'Oncologia) ; Universitat Autònoma de Barcelona
In the last 10 years, major advances have been made in the diagnosis and development of selective therapies for several blood cancers, including B-cell non-Hodgkin lymphoma (B-NHL), a heterogeneous group of malignancies arising from the mature B lymphocyte compartment. [...]
2019 - 10.3389/fgene.2019.00986
Frontiers in genetics, Vol. 10 Núm. OCT (2019) , p. 986  
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