Resultados globales: 6 registros encontrados en 0.02 segundos.
Artículos, Encontrados 6 registros
Artículos Encontrados 6 registros  
1.
27 p, 1.4 MB Epigenetics in a spectrum of myeloid diseases and its exploitation for therapy / Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mutations in genes encoding chromatin regulators are early events contributing to de-veloping asymptomatic clonal hematopoiesis of indeterminate potential and its frequent progression to myeloid diseases with increasing severity. [...]
2021 - 10.3390/cancers13071746
Cancers, Vol. 13 Núm. 7 (january 2021) , art. 1746  
2.
13 p, 1.2 MB Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis / Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Winkler, René (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Casquero, Raquel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Muhar, Matthias (Research Institute of Molecular Pathology (IMP). Vienna BioCenter (VBC)) ; van der Garde, Mark (German Cancer Consortium (DKTK). Partner Site Munich) ; Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martínez Herráez, Carolina (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Bech-Serra, Joan-Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fellner, Michaela (Research Institute of Molecular Pathology (IMP). Vienna BioCenter (VBC)) ; Rathert, Philipp (University Stuttgart) ; Brooks, Nigel (CellCentric. Ltd. Chesterford Research Park) ; Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gentilella, Antonio (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zuber, Johannes (Medical University of Vienna. Vienna BioCenter (VBC)) ; Götze, Katharina S. (Technische Universität München) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The nucleotide analogue azacitidine (AZA) is currently the best treatment option for patients with high-risk myelodysplastic syndromes (MDS). However, only half of treated patients respond and of these almost all eventually relapse. [...]
2021 - 10.1038/s41467-021-26258-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 6060  
3.
11 p, 1.5 MB Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18 / Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Cabezón, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vergara, Sara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Méndez López, Aleix (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Mesa Tudel, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sorigue, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. [...]
2021 - 10.1038/s41598-021-00623-w
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 21145  
4.
21 p, 4.0 MB MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines / Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Carrillo-Reixach, Juan (Institut Germans Trias i Pujol) ; Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Garcia-Jaraquemada, Arce (Institut Germans Trias i Pujol) ; Le Pannérer, Marguerite Marie (Universitat Pompeu Fabra) ; Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Pérez, Ainoha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Del Río-Álvarez, Álvaro (Institut Germans Trias i Pujol) ; Royo, Laura (Institut Germans Trias i Pujol) ; Pérez-González, Beatriz (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ; Raurell Vila, Helena (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ; Acemel, Rafael D. (Universidad Pablo de Olavide) ; Santos-Pereira, José M. (Universidad Pablo de Olavide) ; Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ; Gómez-Skarmeta, José Luís (Centro Andaluz de Biología del Desarrollo (CABD). CSIC-Universidad Pablo de Olavide) ; Pasquali, Lorenzo (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ; Manyé, Josep (Institut Germans Trias i Pujol) ; Armengol, Carolina (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Buschbeck, Marcus (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1. 2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. [...]
2022 - 10.1016/j.celrep.2022.110988
Cell reports, Vol. 39 Núm. 12 (6 2022) , p. 110988  
5.
31 p, 1.4 MB Histone Modifications and Their Targeting in Lymphoid Malignancies / Fernández-Serrano, Miranda (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Winkler, René (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Roué, Gaël (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
In a wide range of lymphoid neoplasms, the process of malignant transformation is associated with somatic mutations in B cells that affect the epigenetic machinery. Consequential alterations in histone modifications contribute to disease-specific changes in the transcriptional program. [...]
2021 - 10.3390/ijms23010253
International journal of molecular sciences, Vol. 23 (december 2021)  
6.
14 p, 3.9 MB Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome / Bereshchenko, O. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Lo Re, O. (Department of Biology. Faculty of Medicine. Masaryk University) ; Nikulenkov, F. (Department of Biology. Faculty of Medicine. Masaryk University) ; Flamini, S. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Kotaskova, J. (University Hospital Brno (República Txeca)) ; Mazza, T. (IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ; Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Giallongo, C. (Division of Hematology. A.O.U. Policlinico-OVE. University of Catania) ; Palumbo, G. (Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia. University of Catania) ; Li Volti, G. (Department of Biomedical and Biotechnological Sciences. University of Catania) ; Pazienza, V. (Gastroenterology Unit. IRCCS Casa Sollievo della Sofferenza) ; Cervinek, L. (University Hospital Brno (República Txeca)) ; Riccardi, C. (Department of Medicine. Department of Philosophy. Social Sciences and Education. University of Perugia) ; Krejci, L. (Department of Biology. Faculty of Medicine. Masaryk University) ; Pospisilova, S. (University Hospital Brno (República Txeca)) ; Stewart, A. F. (Genomics. Biotechnology Center. Center for Molecular and Cellular Bioengineering. Technische Universität Dresden) ; Vinciguerra, M. (International Clinical Research Center. St'Anne University Hospital) ; Universitat Autònoma de Barcelona
Background: Epigenetic regulation is important in hematopoiesis, but the involvement of histone variants is poorly understood. Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell (HSC) disorders characterized by ineffective hematopoiesis. [...]
2019 - 10.1186/s13148-019-0724-z
Clinical Epigenetics, Vol. 11 Núm. 1 (22 2019) , p. 121  

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